Retrospective Analysis of the Multidisciplinary Treatment for 534 Hepatocellular Carcinoma Patients over a 12-Year Period

• Published in: Internal Medicine Vol. 34; no. 7; pp. 623 - 627
• Main Authors: ITO, Toshio, URABE, Yoshiaki, SHIRAGA, Kunihiro, SAKAGUCHI, Kohsaku, HIGASHI, Toshihiro, HINO, Naoki, TSUN, Takao
• Format: Journal Article
• Language: English
• Published: Tokyo The Japanese Society of Internal Medicine 1995; Japanese Society of Internal Medicine
• Subjects: Aged; Biological and medical sciences; Carcinoma, Hepatocellular - mortality; Carcinoma, Hepatocellular - pathology; Carcinoma, Hepatocellular - therapy; chronic liver disease; Combined Modality Therapy; Female; Follow-Up Studies; Gastroenterology. Liver. Pancreas. Abdomen; hepatectomy; Hepatitis B Surface Antigens - analysis; Humans; Liver Neoplasms - mortality; Liver Neoplasms - pathology; Liver Neoplasms - therapy; Liver. Biliary tract. Portal circulation. Exocrine pancreas; Male; Medical sciences; Middle Aged; Neoplasm Staging; percutaneous ethanol injection; Retrospective Studies; Sex Factors; survival; Survival Rate; transcatheter arterial embolization; Tumors; Human; Ethanol; Catheter; Hepatic disease; Malignant tumor; Injection; Survival; Retrospective; Hepatectomy; Percutaneous route; Liver cell carcinoma; Surgery; Digestive diseases; Embolization
• ISSN: 0918-2918; 1349-7235
• DOI: 10.2169/internalmedicine.34.623

Multidisciplinary treatments for 534 patients with hepatocellular carcinoma (HCC) over a 12-year period from 1981 to 1992 were retrospectively studied. Cumulative survival curve of all patients showed a fine hyperbolic curve, and 1-year, 3-year-, 5-year survivals were 66, 33, and 18%, respectively. Survival of female patients was better than male patients, and survival of HBsAg-negative patients was better than that of HBsAg-positive patients. Several background factors such as the Child-Pugh classification, liver function tests or factors, number of tumors, and the size of the main tumor were analyzed, and each factor was related to survival. Survival curves of 3 treatments, hepatectomy, percutaneous ethanol injection (PEI), and transcatheter arterial embolization (TAE)+PEI, overlapped to a large degree. Also the survival curve of the more recent 6-year period from 1987 to 1992 was better than that of the earlier 6-year period from 1981 to 1986. (Internal Medicine 34: 623-627, 1995)