The Expression of Vesicular Glutamate Transporters Defines Two Classes of Excitatory Synapse

The quantal release of glutamate depends on its transport into synaptic vesicles. Recent work has shown that a protein previously implicated in the uptake of inorganic phosphate across the plasma membrane catalyzes glutamate uptake by synaptic vesicles. However, only a subset of glutamate neurons ex...

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Published inNeuron (Cambridge, Mass.) Vol. 31; no. 2; pp. 247 - 260
Main Authors Fremeau, Robert T, Troyer, Matthew D, Pahner, Ingrid, Nygaard, Gro Owren, Tran, Cindy H, Reimer, Richard J, Bellocchio, Elizabeth E, Fortin, Doris, Storm-Mathisen, Jon, Edwards, Robert H
Format Journal Article
LanguageEnglish
Published United States Elsevier Inc 02.08.2001
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Summary:The quantal release of glutamate depends on its transport into synaptic vesicles. Recent work has shown that a protein previously implicated in the uptake of inorganic phosphate across the plasma membrane catalyzes glutamate uptake by synaptic vesicles. However, only a subset of glutamate neurons expresses this vesicular glutamate transporter (VGLUT1). We now report that excitatory neurons lacking VGLUT1 express a closely related protein that has also been implicated in phosphate transport. Like VGLUT1, this protein localizes to synaptic vesicles and functions as a vesicular glutamate transporter (VGLUT2). The complementary expression of VGLUT1 and 2 defines two distinct classes of excitatory synapse.
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ISSN:0896-6273
1097-4199
DOI:10.1016/S0896-6273(01)00344-0