Metabolism in atherosclerotic plaques: immunoregulatory mechanisms in the arterial wall

• Published in: Clinical science (1979) Vol. 136; no. 6; pp. 435 - 454
• Main Authors: Forteza, Maria J, Ketelhuth, Daniel F J
• Format: Journal Article
• Language: English
• Published: England Portland Press Ltd 31.03.2022
• Subjects: Arteries - metabolism; Atherosclerosis - metabolism; Cardiovascular System & Vascular Biology; Humans; Immunity; Immunology & Inflammation; Macrophages - metabolism; Medicin och hälsovetenskap; Plaque, Atherosclerotic - metabolism; Review; T-cells; atherosclerosis; cardiovascular disease; immunomodulation; macrophages; immunometabolism
• ISSN: 0143-5221; 1470-8736; 1470-8736
• DOI: 10.1042/cs20201293

Over the last decade, there has been a growing interest to understand the link between metabolism and the immune response in the context of metabolic diseases but also beyond, giving then birth to a new field of research. Termed 'immunometabolism', this interdisciplinary field explores paradigms of both immunology and metabolism to provided unique insights into different disease pathogenic processes, and the identification of new potential therapeutic targets. Similar to other inflammatory conditions, the atherosclerotic inflammatory process in the artery has been associated with a local dysregulated metabolic response. Thus, recent studies show that metabolites are more than just fuels in their metabolic pathways, and they can act as modulators of vascular inflammation and atherosclerosis. In this review article, we describe the most common immunometabolic pathways characterised in innate and adaptive immune cells, and discuss how macrophages' and T cells' metabolism may influence phenotypic changes in the plaque. Moreover, we discuss the potential of targeting immunometabolism to prevent and treat cardiovascular diseases (CVDs).