Biological actions and molecular effects of resveratrol, pterostilbene, and 3′-hydroxypterostilbene

• Published in: Yàowu shi͡p︡in fenxi Vol. 25; no. 1; pp. 134 - 147
• Main Authors: Tsai, Hui-Yun, Ho, Chi-Tang, Chen, Yu-Kuo
• Format: Journal Article
• Language: English
• Published: China (Republic : 1949- ) Elsevier B.V 01.01.2017; Food and Drug Administration; Taiwan Food and Drug Administration
• Subjects: 3′-hydroxypterostilbene; Apoptosis; autophagy; Berries; bioavailability; biological actions; Cancer; Carcinogens; Cell cycle; cell cycle checkpoints; Cell death; Chemical compounds; chemical structure; chemoprevention; Chemotherapy; Chronic illnesses; Diabetes mellitus; dietary nutrient sources; drug therapy; drugs; Dyslipidemia; Fruits; grapes; Humans; In vivo methods and tests; in vivo studies; Kinases; Medicinal plants; Molecular chains; neoplasm cells; neoplasms; Nuts; Organic chemistry; Peanuts; Phagocytosis; Polyphenols; pterostilbene; red wines; Resveratrol; Review; Rodents; small fruits; Stilbene; stilbenes; Stilbenes - pharmacology; Vitaceae; Wines; stilbenes; 3′-hydroxypterostilbene; biological actions; bioavailability; resveratrol; pterostilbene
• ISSN: 1021-9498; 2224-6614
• DOI: 10.1016/j.jfda.2016.07.004

Stilbenes are a class of polyphenolic compounds, naturally found in a wide variety of dietary sources such as grapes, berries, peanuts, red wine, and some medicinal plants. There are several well-known stilbenes including trans-resveratrol, pterostilbene, and 3′-hydroxypterostilbene. The core chemical structure of stilbene compounds is 1,2-diphenylethylene. Recently, stilbenes have attracted extensive attention and interest due to their wide range of health-beneficial effects such as anti-inflammation, -carcinogenic, -diabetes, and -dyslipidemia activities. Moreover, accumulating in vitro and in vivo studies have reported that stilbene compounds act as inducers of multiple cell-death pathways such as apoptosis, cell cycle arrest, and autophagy for chemopreventive and chemotherapeutic agents in several types of cancer cells. The aim of this review is to highlight recent molecular findings and biological actions of trans-resveratrol, pterostilbene, and 3′-hydroxypterostilbene. [Display omitted]