Black tea extract, thearubigin fraction, counteract the effects of botulinum neurotoxins in mice

Botulinum neurotoxin type A (BoNT/A, 1.5 nM) completely inhibited indirectly evoked twitches in in vitro mouse phrenic nerve‐diaphragm preparations within 40 – 45 min. Black tea extract, thearubigin fraction (TRB), mixed with BoNT/A blocked the inhibitory effect of the toxin. The protective effect o...

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Bibliographic Details
Published inBritish journal of pharmacology Vol. 132; no. 4; pp. 797 - 798
Main Authors Satoh, Eiki, Ishii, Toshiaki, Shimizu, Yoshio, Sawamura, Shin‐ichi, Nishimura, Masakazu
Format Journal Article
LanguageEnglish
Published Oxford, UK Blackwell Publishing Ltd 01.02.2001
Nature Publishing
Subjects
Animals
Biological and medical sciences
botulinum neurotoxin
botulinum toxin
Botulinum Toxins, Type A - toxicity
botulism
Catechin - analogs & derivatives
Catechin - pharmacology
Clostridium botulinum
Female
General pharmacology
In Vitro Techniques
Male
Medical sciences
Mice
Neuromuscular Junction - drug effects
Neuromuscular Junction - physiology
Pharmacognosy. Homeopathy. Health food
Pharmacology. Drug treatments
Phenols - pharmacology
Plant Extracts - pharmacology
Polyphenols
prophylaxis
Special Reports
Tea
tetanus toxin
thearubigin
Thearubigin fraction
thearubigins
Metalloendopeptidases
Peripheral neuropathy
Medicinal plant
Bontoxilysin
Phrenic nerve
Peripheral nerve disease
Nervous system diseases
Enzyme
Pharmacognosy
Rodentia
Neuroprotective agent
Neuromuscular transmission
In vitro
Infection
Peptidases
Nerve muscle preparation
Tea
Vertebrata
Mammalia
Botulism
Mouse
Animal
Neurotoxin
Plant origin
Theaflavin
Bacteriosis
Hydrolases
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Summary:Botulinum neurotoxin type A (BoNT/A, 1.5 nM) completely inhibited indirectly evoked twitches in in vitro mouse phrenic nerve‐diaphragm preparations within 40 – 45 min. Black tea extract, thearubigin fraction (TRB), mixed with BoNT/A blocked the inhibitory effect of the toxin. The protective effect of TRB extended to botulinum neurotoxins types B and E (BoNT/B and BoNT/E) and tetanus toxin, but not to tetrodotoxin. TRB was also effective against oral toxicity of BoNT/A, B and E. Thus, TRB may be of potential benefit in protecting the paralytic actions of botulinum neurotoxins (BoNTs), but its use is limited by mixing with the toxin. British Journal of Pharmacology (2001) 132, 797–798; doi:10.1038/sj.bjp.0703883
Bibliography:ObjectType-Article-2
SourceType-Scholarly Journals-1
ObjectType-Feature-1
content type line 23
ISSN:0007-1188
1476-5381
DOI:10.1038/sj.bjp.0703883