高血压肾损害患者IL-6-174基因多态性及其与贝那普利治疗反应的相关性研究

目的分析白细胞介素-6（IL-6）-174基因多态性与高血压肾损害患者之间，及其与贝那普利治疗反应的相关性。方法选取284例高血压病患者，根据24h尿蛋白排泄率将患者分为高血压组152例（24h尿蛋白排泄率＜20μg/min）和高血压肾损害组132例（24h尿蛋白排泄率≥20μg/min）；同时选取160例健康体检者作为正常血压组。所有入选对象留取血清标本，检测IL-6水平（酶联免疫检测法）及IL-6-174基因多态性（PCR-RFLP法）。以贝那普利对高血压肾损害患者进行干预，比较IL-6-174不同基因型对贝那普利的治疗反应。结果高血压患者的IL-6-174以CC基因型为多见，其次为GG、...

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Bibliographic Details
Published in天津医药 Vol. 45; no. 5; pp. 497 - 501
Main Author 于欣;于美玲;张德凯;楚元奎;张怡清;白静;邢译文;杨震
Format Journal Article
LanguageChinese
Published 宁夏医科大学临床学院医学检验系 750004%宁夏医科大学总医院药剂科%宁夏医科大学总医院心脏中心 2017
Subjects
白细胞介素6;多态现象,遗传;血管紧张素转换酶抑制药;高血压肾损害;贝那普利
多态现象,遗传
贝那普利
genetic
angiotensin-converting enzyme inhibitors
血管紧张素转换酶抑制药
白细胞介素6
hypertensive renal damage
Benazepril
polymorphism
高血压肾损害
interleukin-6
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Summary:目的分析白细胞介素-6（IL-6）-174基因多态性与高血压肾损害患者之间，及其与贝那普利治疗反应的相关性。方法选取284例高血压病患者，根据24h尿蛋白排泄率将患者分为高血压组152例（24h尿蛋白排泄率＜20μg/min）和高血压肾损害组132例（24h尿蛋白排泄率≥20μg/min）；同时选取160例健康体检者作为正常血压组。所有入选对象留取血清标本，检测IL-6水平（酶联免疫检测法）及IL-6-174基因多态性（PCR-RFLP法）。以贝那普利对高血压肾损害患者进行干预，比较IL-6-174不同基因型对贝那普利的治疗反应。结果高血压患者的IL-6-174以CC基因型为多见，其次为GG、GC，G/C等位基因频率分别为47%、53%。高血压肾损害患者的IL-6-174以GG基因型最为多见，其次为GC和CC，G/C等位基因频率分别为68%、32%，基因型及G/C等位基因频率比较差异有统计学意义（P＜0.05）。IL-6-174的CC基因型贝那普利治疗前后尿蛋白排泄率和IL-6的改变幅度最大，其次是GC和GG基因型，3组间比较差异有统计学意义（P＜0.05）。结论IL-6-174的G等位基因频率与宁夏高血压肾损害相关，高血压肾损害患者的IL-6-174的基因型以GG最为多见。IL-6-174的CC基因型对贝那普利治疗的反应最佳，尿蛋白排泄率下降最快。
Bibliography:Objective To study the relationship between the genetic polymorphism of interleukine-6(IL-6)-174andthe response to benazepril treatment in patients with hypertensive renal damage.Methods Two hundred and eighty-fourpatients with hypertension were enrolled in this study.The hypertensive renal damage was defined by the measurement ofurinary albumin excretion rate(UAER).One hundred and sixty healthy subjects were enrolled simultaneously as controlgroup.Blood samples were obtained from all the subjects,and plasma levels of IL-6and the genotype of gene IL-6-174were detected.The patients with hypertensive renal damage were treated with benazepril for16weeks.The responses wereevaluated by the changes of UAER level to benazepril in different genotypes.Results Genotype CC was the most commonof the gene IL-6-174in patients with hypertension,followed by GG and GC successively,with the G/C allele frequency of47%and53%(P<0.05),while in patients with hypertensive renal damage,GG was the most common genotype of the geneIL
ISSN:0253-9896
DOI:10.11958/20161498