The immunological synapse

The molecular interactions underlying regulation of the immune response take place in a nanoscale gap between T cells and antigen-presenting cells, termed the immunological synapse. If these interactions are regulated appropriately, the host is defended against a wide range of pathogens and deranged...

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Bibliographic Details
Published inCancer immunology research Vol. 2; no. 11; p. 1023
Main Author Dustin, Michael L
Format Journal Article
LanguageEnglish
Published United States 01.11.2014
Subjects
Animals
Humans
Immunological Synapses - immunology
Immunotherapy
Neoplasms - immunology
Tumor Escape - immunology
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Summary:The molecular interactions underlying regulation of the immune response take place in a nanoscale gap between T cells and antigen-presenting cells, termed the immunological synapse. If these interactions are regulated appropriately, the host is defended against a wide range of pathogens and deranged host cells. If these interactions are disregulated, the host is susceptible to pathogens or tumor escape at one extreme and autoimmunity at the other. Strategies targeting the synapse have helped to establish immunotherapy as a mainstream element in cancer treatment. This Masters' primer will cover the basics of the immunological synapse and some of the applications to tumor immunology.
ISSN:2326-6074
DOI:10.1158/2326-6066.cir-14-0161