Correlations between Antepartum Maternal Metabolism and Intelligence of Offspring

• Published in: The New England journal of medicine Vol. 325; no. 13; pp. 911 - 916
• Main Authors: Rizzo, Thomas, Metzger, Boyd E, Burns, Kayreen, Burns, William J
• Format: Journal Article
• Language: English
• Published: Boston, MA Massachusetts Medical Society 26.09.1991
• Subjects: 3-Hydroxybutyric Acid; Age; Biological and medical sciences; Blood Glucose - metabolism; Child Development; Child, Preschool; Children & youth; Developmental psychology; Diabetes; Diabetic ketoacidosis; Fatty acids; Fatty Acids, Nonesterified - blood; Female; Fundamental and applied biological sciences. Psychology; Glucose; Hemoglobin A - metabolism; Hospitals; Humans; Hydroxybutyrates - blood; Hypoglycemia; Infant, Newborn; Insulin; Intelligence; Metabolism; Mothers; Plasma; Pregnancy; Pregnancy - metabolism; Pregnancy in Diabetics - metabolism; Psychology. Psychoanalysis. Psychiatry; Psychology. Psychophysiology; Stanford-Binet Test; Urine; Womens health; Endocrinopathy; Human; Intelligence; Diabetes mellitus; Memory; Central nervous system; Cognition; Epidemiology; Pregnancy; Newborn; Development; Female; General metabolism; Brain (vertebrata)
• ISSN: 0028-4793; 1533-4406
• DOI: 10.1056/NEJM199109263251303

DURING pregnancy, most maternal fuels gain access to the developing conceptus in a concentration-dependent fashion. 1 Circulating maternal fuels may affect the quantitative and qualitative characteristics of the nutrient mixture in which organogenesis and cellular replication, differentiation, and functional maturation occur. 1 , 2 Alterations in maternal fuels may have long-range effects on the offspring by modifying terminally differentiating, poorly replicating cells during critical phases of embryonic or fetal life 3 , 4 ; in this context maternal fuels may have actions above and beyond their simple nutrient functions. Fuel disturbances early in gestation may influence organogenesis in a classic teratogenic fashion, whereas disturbances occurring later in . . .