Gut Microbiota and Type 2 Diabetes Mellitus: Association, Mechanism, and Translational Applications

• Published in: Mediators of inflammation Vol. 2021; pp. 1 - 12
• Main Authors: Zhang, Lili, Chu, Jinjin, Hao, Wenhao, Zhang, Jiaojiao, Li, Haibo, Yang, Chunjuan, Yang, Jinghan, Chen, Xiaohua, Wang, Honggang
• Format: Journal Article
• Language: English
• Published: United States Hindawi 17.08.2021; John Wiley & Sons, Inc; Wiley
• Subjects: Antifungal agents; Bacteria; Branched chain amino acids; Deoxycholic acid; Diabetes; Diabetes mellitus (non-insulin dependent); Diabetes Mellitus, Type 2 - metabolism; Disease; Esters; Fatty acids; Fatty Acids, Volatile; Fecal Microbiota Transplantation; Fecal microflora; Gastrointestinal Microbiome - physiology; Glucose; Gut microbiota; Humans; Imidazole; Inflammation; Insulin resistance; Intestinal microflora; Lipopolysaccharides; Metabolic disorders; Metabolites; Microbiota; Microbiota (Symbiotic organisms); Pathogenesis; Physiological aspects; Prevention; Probiotics; Probiotics - therapeutic use; Propionic acid; Review; Translation; Transplantation; Type 2 diabetes; China

Gut microbiota has attracted widespread attention due to its crucial role in disease pathophysiology, including type 2 diabetes mellitus (T2DM). Metabolites and bacterial components of gut microbiota affect the initiation and progression of T2DM by regulating inflammation, immunity, and metabolism....