Ginsenosides: the need to move forward from bench to clinical trials

Panax ginseng, known as Koran ginseng, one of the most commonly used traditional plants, has been demonstrated to show a wide range of pharmacological applications. Ginsenosides are the major active ingredients found in ginseng and are responsible for the biological and pharmacological activities, s...

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Bibliographic Details
Published inJournal of ginseng research Vol. 43; no. 3; pp. 361 - 367
Main Authors Yu, Seung Eun, Mwesige, Benjamin, Yi, Young-Su, Yoo, Byong Chul
Format Journal Article
LanguageEnglish
Published Korea (South) Elsevier B.V 01.07.2019
고려인삼학회
Elsevier
Subjects
Clinical trial
Ginseng
Ginsenoside
Protopanaxadiol
Protopanaxatriol
Short Review
기타의약학
Protopanaxadiol
Clinical trial
Protopanaxatriol
Ginseng
Ginsenoside
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Summary:Panax ginseng, known as Koran ginseng, one of the most commonly used traditional plants, has been demonstrated to show a wide range of pharmacological applications. Ginsenosides are the major active ingredients found in ginseng and are responsible for the biological and pharmacological activities, such as antioxidation, antiinflammation, vasorelaxation, and anticancer actions. Existing studies have mostly focused on identifying and purifying single ginsenosides and investigating pharmacological activities and molecular mechanisms in cells and animal models. However, ginsenoside studies based on clinical trials have been very limited. Therefore, this review aimed to discuss the currently available clinical trials on ginsenosides and provide insights and future directions for developing ginsenosides as efficacious and safe drugs for human disease.
Bibliography:ObjectType-Article-2
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These authors contributed equally to this work.
ISSN:1226-8453
2093-4947
DOI:10.1016/j.jgr.2018.09.001