Ameliorative effects of ginseng and ginsenosides on rheumatic diseases

• Published in: Journal of ginseng research Vol. 43; no. 3; pp. 335 - 341
• Main Author: Yi, Young-Su
• Format: Journal Article
• Language: English
• Published: Korea (South) Elsevier B.V 01.07.2019; 고려인삼학회; Elsevier
• Subjects: Ginseng; Ginsenosides; Inflammation; Macrophages; Review; Rheumatic diseases; 기타의약학; COL; RNAKL; BMP; PPD; Rheumatic diseases; CK; Inflammation; Macrophages; SLE; Ginsenosides; RA; ACAN; PAMP; PRR; OA; ACLT; PPT; CIA; Ginseng; LTMMR; DAMP; RA, Rheumatoid arthritis; ACLT, Anterior cruciate ligament transection; LTMMR, Ligament transection and medial meniscus resection; PAMP, Pathogen-associated molecular pattern; ACAN, Aggrecan; CIA, Collagen-induced arthritic; CK, Compound K; RNAKL, Receptor activator of NF-κB ligand; PPT, Protopanaxatriol; PRR, Pattern-recognition receptor; SLE, Systemic lupus erythematosus; COL, Collagen; DAMP, Danger-associated molecular pattern; OA, Osteoarthritis; BMP, Bone morphogenetic protein; PPD, Protopanaxadiol
• ISSN: 1226-8453; 2093-4947
• DOI: 10.1016/j.jgr.2018.04.004

Inflammation is a host-defensive innate immune response to protect the body from pathogenic agents and danger signals induced by cellular changes. Although inflammation is a host-defense mechanism, chronic inflammation is considered a major risk factor for the development of a variety of inflammatory autoimmune diseases, such as rheumatic diseases. Rheumatic diseases are systemic inflammatory and degenerative diseases that primarily affect connective tissues and are characterized by severe chronic inflammation and degeneration of connective tissues. Ginseng and its bioactive ingredients, genocides, have been demonstrated to have antiinflammatory activity and pharmacological effects on various rheumatic diseases by inhibiting the expression and production of inflammatory mediators. Literature in this review was searched in a PubMed site of National Center for Biotechnology Information. The studies reporting the preventive and therapeutic effects of ginseng and ginsenosides on the pathogenesis of rheumatic diseases were discussed and summarized. Ginseng and ginsenosides play an ameliorative role on rheumatic diseases, and this review provides new insights into ginseng and ginsenosides as promising agents to prevent and treat rheumatic diseases.