Antibodies against Pneumococcal Capsular Polysaccharides and Natural Anti-Galactosyl (Alpha-Gal) in Patients with Humoral Immunodeficiencies

• Published in: Journal of Immunology Research Vol. 2017; pp. 7304658 - 8
• Main Authors: Kralickova, P., Kuhnova, J., Soucek, O., Vodarek, P., Zak, P., Simkovic, M., Motyckova, M., Smolej, L., Mala, E., Andrys, C., Krejsek, J., Thon, V.
• Format: Journal Article
• Language: English
• Published: Egypt Hindawi 01.01.2017; John Wiley & Sons, Inc; Hindawi Limited
• Subjects: Age; Antigens; Bacterial infections; Capsular polysaccharides; Chronic lymphocytic leukemia; Common variable immunodeficiency; Hematology; Hospitals; Immune system; Immunoglobulin A; Immunoglobulin G; Immunoglobulin M; Immunoglobulins; Immunology; Infectious diseases; Leukemia; Medicine; Older people; Polysaccharides; Production capacity; Saccharides; Streptococcus infections; Vaccines; Womens health; Czech Republic
• ISSN: 2314-8861; 2314-7156
• DOI: 10.1155/2017/7304658

Humoral deficiencies represent a broad group of disorders. The aim of the study was to compare the levels of antibodies against pneumococcal capsular polysaccharides (anti-PCP) and natural anti-galactosyl (anti-Gal) antibodies in (1) patients with chronic lymphocytic leukaemia (CLL), (2) patients with common variable immunodeficiency (CVID), and (3) a healthy population and to explore their diagnostic and prognostic potential. Serum immunoglobulin levels and levels of anti-Gal IgG, IgA, and IgM and anti-PCP IgG and IgG2 were determined in 59 CLL patients, 30 CVID patients, and 67 healthy controls. Levels of IgG, IgA, IgM, anti-Gal IgA, anti-Gal IgM, and anti-PCP IgA were lower in CLL and CVID patients than in healthy controls (p value for all parameters < 0.0001). Decrease in the levels of IgA, IgM, anti-Gal IgA, and anti-PCP IgA was less pronounced in the CLL group than in the CVID group. IgA decline, anti-Gal IgA, anti-PCP IgA, and anti-PCP IgG2 were negatively correlated with CLL stage. We devise the evaluation of anti-Gal antibodies to be a routine test in humoral immunodeficiency diagnostics, even in cases of immunoglobulin substitution therapy. Significant reductions, mainly in anti-Gal IgA, IgM, and anti-PCP IgA levels, may have prognostic importance in CLL patients.