Protective effect of Pasteurella multocida cell-free antigen and toxoid against challenge with toxigenic strains of Pasteurella multocida in mice

The cell-free antigen (CFA) obtained from the culture supernatant of Pasteurella multocida (P. multocida) and the toxin (PMT) purified from CFA were inactivated and mixed with oil adjuvant to prepare a trial vaccine. Both of the mice immunized with CFA and PMT toxoid vaccine were noticeably protecte...

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Published inJournal of Veterinary Medical Science Vol. 65; no. 6; pp. 737 - 740
Main Authors Uchida, C. (Kyoto Biken Lab., Uji (Japan)), Kimura, Y, Kubota, S, Sasaki, O
Format Journal Article
LanguageEnglish
Published Japan JAPANESE SOCIETY OF VETERINARY SCIENCE 01.06.2003
Japan Science and Technology Agency
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Summary:The cell-free antigen (CFA) obtained from the culture supernatant of Pasteurella multocida (P. multocida) and the toxin (PMT) purified from CFA were inactivated and mixed with oil adjuvant to prepare a trial vaccine. Both of the mice immunized with CFA and PMT toxoid vaccine were noticeably protected against intratracheal challenge with toxigenic strains of P. multocida. Nevertheless, the protective indices of the mice immunized with CFA vaccine indicate that it is more protective and clears away the bacteria more promptly than in the mice immunized with PMT vaccine. The results suggested that CFA would possibly be good as an effective antigen to toxigenic strains of P. multocida infection.
Bibliography:2004003788
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ISSN:0916-7250
1347-7439
DOI:10.1292/jvms.65.737