Brown Adipose Crosstalk in Tissue Plasticity and Human Metabolism

Abstract Infants rely on brown adipose tissue (BAT) as a primary source of thermogenesis. In some adult humans, residuals of brown adipose tissue are adjacent to the central nervous system and acute activation increases metabolic rate. Brown adipose tissue (BAT) recruitment occurs during cold acclim...

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Bibliographic Details
Published inEndocrine reviews Vol. 41; no. 1; pp. 53 - 65
Main Authors Scheele, Camilla, Wolfrum, Christian
Format Journal Article
LanguageEnglish
Published US Oxford University Press 01.02.2020
Subjects
Acclimation
Acclimatization
Adipogenesis
Adipogenesis - physiology
Adipose tissue
Adipose tissue (brown)
Adipose Tissue, Brown - cytology
Adipose Tissue, Brown - physiology
Adipose Tissue, White - cytology
Adipose Tissue, White - physiology
Adipose tissues
Adult
Angiogenesis
Animals
Axonogenesis
Cell interactions
Cell Plasticity - physiology
Central nervous system
Cold acclimation
Crosstalk
Energy consumption
Energy Metabolism - physiology
Humans
Immune system
Infant
Infants
Metabolic rate
Metabolism
Muscle, Skeletal - physiology
Muscles
Nervous system
Physiological aspects
Reviews
Skeletal muscle
Thermogenesis
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Summary:Abstract Infants rely on brown adipose tissue (BAT) as a primary source of thermogenesis. In some adult humans, residuals of brown adipose tissue are adjacent to the central nervous system and acute activation increases metabolic rate. Brown adipose tissue (BAT) recruitment occurs during cold acclimation and includes secretion of factors, known as batokines, which target several different cell types within BAT, and promote adipogenesis, angiogenesis, immune cell interactions, and neurite outgrowth. All these processes seem to act in concert to promote an adapted BAT. Recent studies have also provided exciting data on whole body metabolic regulation with a broad spectrum of mechanisms involving BAT crosstalk with liver, skeletal muscle, and gut as well as the central nervous system. These widespread interactions might reflect the property of BAT of switching between an active thermogenic state where energy is highly consumed and drained from the circulation, and the passive thermoneutral state, where energy consumption is turned off. (Endocrine Reviews 41: XXX – XXX, 2020) Graphical Abstract Graphical Abstract
Bibliography:ObjectType-Article-2
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ISSN:0163-769X
1945-7189
DOI:10.1210/endrev/bnz007