Association of bovine uterine involution disturbances with serum neuropeptide concentrations

• Published in: Veterinary World Vol. 13; no. 9; pp. 1854 - 1857
• Main Authors: Abultdinova, Aida, Jakupov, Isatay, Roth, Joachim, Failing, Klaus, Wehrend, Axel, Sickinger, Marlene
• Format: Journal Article
• Language: English
• Published: India Veterinary World 01.09.2020
• Subjects: Analysis; Biological products; Dairy cattle; dairy cow; diagnostics; Farms; IL-1β; inflammation; Interleukins; Intestine; Neuropeptides; Serum levels; Statistical analysis; Substance P; Uterus; uterus involution; Vasoactive agents; Vasoactive intestinal peptide; Germany; neuropeptides; diagnostics; dairy cow; uterus involution; inflammation
• ISSN: 0972-8988; 2231-0916
• DOI: 10.14202/vetworld.2020.1854-1857

Puerperal diseases influence fertility and should be diagnosed as soon as possible. This study aimed to evaluate the applicability of serum concentrations of substance P (SP), vasoactive intestinal polypeptide (VIP), and interleukin (IL)1β in the early diagnosis of uterine involution disturbances. Blood serum samples of 86 dairy cows from six different farms were harvested within the first 20 days after calving from cows with uterine involution disturbances and healthy controls, respectively. Serum concentrations for SP, VIP, and IL-1β were determined using commercially available ELISA test kits. Statistical analyses included timely changes in blood serum levels and group comparisons of healthy cows and cows with uterine disease. SP concentrations increased significantly within 20 days after calving (p<0.04) with no significant difference observed between the groups. Moreover, no significant differences were found between VIP and log IL-1β. Results showed that none of the examined serum parameters seems suitable as indicator of uterine involution disorders. Due to the timely changes in serum concentrations of SP after calving, a correlation to diseases might not be precluded. Further research is needed as regards the establishment of normative values concerning this parameter.