UCS1025A, a Novel Antibiotic Produced by Acremonium sp

• Published in: Journal of antibiotics Vol. 53; no. 3; pp. 294 - 296
• Main Authors: NAKAI, RYUICHIRO, OGAWA, HARUMI, ASAI, AKIRA, ANDO, KATSUHIKO, AGAISUMA, TSUTOMU, MAISUMIYA, SHIGEKI, AKINAGA, SHIRO, YAMASHITA, YOSHINORI, MIZUKAMI, TAMIO
• Format: Journal Article
• Language: English
• Published: TOKYO JAPAN ANTIBIOTICS RESEARCH ASSOCIATION 01.03.2000; JAPAN ANTIBIOT RES ASSN; Japan Antibiotics Research Association
• Subjects: Acremonium; Acremonium - classification; Acremonium - growth & development; Acremonium - metabolism; Antibacterial agents; Antibiotics, Antineoplastic - chemistry; Antibiotics, Antineoplastic - metabolism; Antibiotics, Antineoplastic - pharmacology; Antibiotics. Antiinfectious agents. Antiparasitic agents; Antineoplastic agents; Bacteria - drug effects; Biological and medical sciences; Biotechnology & Applied Microbiology; General aspects; Humans; Immunology; Life Sciences & Biomedicine; Medical sciences; Microbial Sensitivity Tests; Microbiology; Pharmacology & Pharmacy; Pharmacology. Drug treatments; Pyrrolizidine Alkaloids - chemistry; Pyrrolizidine Alkaloids - metabolism; Pyrrolizidine Alkaloids - pharmacology; Science & Technology; Tumor Cells, Cultured - drug effects; UCS1025A; Antineoplastic agent; Acremonium; Fermentation; In vitro; Biological activity; Fungi; Antibiotic; Minimum inhibitory concentration; Microorganism culture; Fungi Imperfecti; Antibacterial agent; Tumor cell; Physicochemical properties; Thallophyta
• ISSN: 0021-8820; 1881-1469
• DOI: 10.7164/antibiotics.53.294

In the course of our screening for antitumor antibiotics, two novel compounds, UCS1025A and B, were isolated from Acremonium sp. KY4917. UCS1025A exhibited antimicrobial activity, and antiproliferative activity against human tumor cell lines. In this paper, we describe the taxonomy of the producing organism, fermentation, isolation, physico-chemical properties and biological activities of UCS1025A and B.