Comparative genomics: the bacterial pan-genome

Bacterial genome sequencing has become so easy and accessible that the genomes of multiple strains of more and more individual species have been and will be generated. These data sets provide for in depth analysis of intra-species diversity from various aspects. The pan-genome analysis, whereby the...

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Published inCurrent opinion in microbiology Vol. 11; no. 5; pp. 472 - 477
Main Authors Tettelin, Hervé, Riley, David, Cattuto, Ciro, Medini, Duccio
Format Journal Article
LanguageEnglish
Published Kidlington Elsevier Ltd 01.10.2008
Elsevier
Subjects
Bacteria
Bacteria - genetics
Bacteriology
Biological and medical sciences
Fundamental and applied biological sciences. Psychology
Genetic Variation
Genome, Bacterial
Genomics - methods
Microbiology
Miscellaneous
Pathology
Synteny
Bacteria
Review
Genome
Genomics
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Summary:Bacterial genome sequencing has become so easy and accessible that the genomes of multiple strains of more and more individual species have been and will be generated. These data sets provide for in depth analysis of intra-species diversity from various aspects. The pan-genome analysis, whereby the size of the gene repertoire accessible to any given species is characterized together with an estimate of the number of whole genome sequences required for proper analysis, is being increasingly applied. Different models exist for the analysis and their accuracy and applicability depend on the case at hand. Here we discuss current models and suggest a new model of broad applicability, including examples of its implementation.
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ISSN:1369-5274
1879-0364
DOI:10.1016/j.mib.2008.09.006