Tuned Morphological Electrospun Hydroxyapatite Nanofibers via pH

• Published in: Journal of bionics engineering Vol. 9; no. 4; pp. 478 - 483
• Main Authors: Song, Xiaofeng, Ling, Fengguang, Li, Haotian, Gao, Zhantuan, Chen, Xuesi
• Format: Journal Article
• Language: English
• Published: Singapore Elsevier Ltd 01.12.2012; Springer Singapore
• Subjects: Artificial Intelligence; Biochemical Engineering; Bioinformatics; Biomaterials; Biomedical Engineering and Bioengineering; Biomedical Engineering/Biotechnology; Biomedical materials; Bones; Electrospinning; Engineering; Hydroxyapatite; Nanofibers; pH值; Scanning electron microscopy; sol; Surgical implants; 傅立叶变换红外光谱; 形态; 扫描电子显微镜; 纳米纤维; 羟基磷灰石; 透射电子显微镜; 静电; pH; sol; hydroxyapatite; electrospinning
• ISSN: 1672-6529; 2543-2141
• DOI: 10.1016/S1672-6529(11)60143-1

The concept of biocompatible, osteoconductive and noninflammatory material mimicking the structure of natural bone has generated a considerable interest in recent decades. Hydroxyapatite (HA) is an important bionic material that is used for bone grafting in osseous defects and drug carriers. HA with various morphologies and surface properties have been widely investigated. In this paper, HA nanofibers are produced through a combination of electrospinning and sol-gel technique. The morphologies, composition and structure are investigated by Scanning Electron Microscopy (SEM), Thermogravimetic Analysis (TGA), Fourier Transform Infrared (FTIR), X-ray Diffraction (XRD) patterns, Transmission Electron Microscopy (TEM). The results show that HA nanofibers are even and well-crystallized, and pH is crucial for producing HA nanofibers. With the change of pH from 4 to 9, nanofibers grow densely along (210) plane and become compact while surface area, pore volume and pore size decrease correspondingly. The synthesized HA nanofibers are nontoxic and safe. Zn can be also incorporated into HA nanofibers, which will endow them with more perfect function.