Efficient and persistent gene transfer of AAV-CFTR in maxillary sinus

Adeno-associated virus (AAV) is a naturally replication-deficient DNA parvovirus that has been tested as a possible vehicle for gene therapy for cystic fibrosis. Preliminary tests using the virus in the maxillary sinuses demonstrate encouraging results.

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Bibliographic Details
Published inThe Lancet (British edition) Vol. 351; no. 9117; pp. 1702 - 1703
Main Authors Wagner, John A, Reynolds, Thomas, Moran, Mary Lynn, Moss, Richard B, Wine, Jeffrey J, Flotte, Terence R, Gardner, Phyllis
Format Journal Article
LanguageEnglish
Published London Elsevier Ltd 06.06.1998
Lancet
Elsevier Limited
Subjects
Biological and medical sciences
Clinical Trials, Phase I as Topic
Cystic fibrosis
Cystic Fibrosis Transmembrane Conductance Regulator - genetics
Cystic Fibrosis Transmembrane Conductance Regulator - therapeutic use
Dependovirus - genetics
Gene Transfer Techniques
Genes
Genetic Vectors
Humans
Maxillary Sinusitis - therapy
Medical sciences
Pharmacology. Drug treatments
Polymerase Chain Reaction
Randomized Controlled Trials as Topic
Respiratory system
Viruses
Human
Respiratory disease
Metabolic diseases
Cystic fibrosis
Sinusitis
Genetic disease
Polymerase chain reaction
Treatment
Maxillary sinus
Phase I trial
Digestive diseases
ENT disease
Paranasal sinus disease
Molecular biology
Gene therapy
Pancreatic disease
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Summary:Adeno-associated virus (AAV) is a naturally replication-deficient DNA parvovirus that has been tested as a possible vehicle for gene therapy for cystic fibrosis. Preliminary tests using the virus in the maxillary sinuses demonstrate encouraging results.
Bibliography:SourceType-Other Sources-1
ObjectType-Article-2
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ObjectType-Correspondence-1
ISSN:0140-6736
1474-547X
DOI:10.1016/S0140-6736(05)77740-0