Hypoxia and hypoxia inducible factors in tumor metabolism

• Published in: Cancer letters Vol. 356; no. 2; pp. 263 - 267
• Main Authors: Zeng, Wen, Liu, Peiyi, Pan, Weimin, Singh, Shree Ram, Wei, Yiyong
• Format: Journal Article
• Language: English
• Published: Ireland Elsevier Ireland Ltd 28.01.2015; Elsevier Limited
• Subjects: Angiogenesis; Apoptosis; Apoptosis - physiology; Binding sites; Cancer; Cancer therapies; Cell Hypoxia; Citric Acid Cycle - physiology; Deoxyribonucleic acid; DNA; DNA repair; DNA Repair - genetics; Energy Metabolism - physiology; Enzymes; Glucose - metabolism; Glycolysis - physiology; Hematology, Oncology and Palliative Medicine; HIFs; Humans; Hypoxia; Hypoxia-Inducible Factor 1 - metabolism; Kinases; Lipid Metabolism; Lipids; Metabolism; Mitochondria - metabolism; Neoplasms - metabolism; Phosphorylation; Radiation therapy; Tumor; Tumor Microenvironment; Tumors; Hypoxia; Tumor; Tumor microenvironment; Metabolism; HIFs; Apoptosis

Abstract Because of the abnormal vasculature, most growing solid tumors contain regions that experience either acute or chronic hypoxia. However, tumor cells can maintain a high glycolytic rate even when there is enough oxygen supply. Hypoxia-inducible factors (HIFs) play crucial role in the respons...