Hypoxia and hypoxia inducible factors in tumor metabolism

• Published in: Cancer letters Vol. 356; no. 2; pp. 263 - 267
• Main Authors: Zeng, Wen, Liu, Peiyi, Pan, Weimin, Singh, Shree Ram, Wei, Yiyong
• Format: Journal Article
• Language: English
• Published: Ireland Elsevier Ireland Ltd 28.01.2015; Elsevier Limited
• Subjects: Angiogenesis; Apoptosis; Apoptosis - physiology; Binding sites; Cancer; Cancer therapies; Cell Hypoxia; Citric Acid Cycle - physiology; Deoxyribonucleic acid; DNA; DNA repair; DNA Repair - genetics; Energy Metabolism - physiology; Enzymes; Glucose - metabolism; Glycolysis - physiology; Hematology, Oncology and Palliative Medicine; HIFs; Humans; Hypoxia; Hypoxia-Inducible Factor 1 - metabolism; Kinases; Lipid Metabolism; Lipids; Metabolism; Mitochondria - metabolism; Neoplasms - metabolism; Phosphorylation; Radiation therapy; Tumor; Tumor Microenvironment; Tumors; Hypoxia; Tumor; Tumor microenvironment; Metabolism; HIFs; Apoptosis
• ISSN: 0304-3835; 1872-7980
• DOI: 10.1016/j.canlet.2014.01.032

Abstract Because of the abnormal vasculature, most growing solid tumors contain regions that experience either acute or chronic hypoxia. However, tumor cells can maintain a high glycolytic rate even when there is enough oxygen supply. Hypoxia-inducible factors (HIFs) play crucial role in the response of tumor cells to this distinct microenvironment by shifting energy production from mitochondria towards glycolysis. In this review, we focus on the metabolism of tumor cell survival in hypoxic microenvironments. Furthermore, we also emphasize the mechanisms by which hypoxia and HIFs regulate tumor metabolism.