Tolvaptan for Hyponatremia

To the Editor: Schrier and colleagues (Nov. 16 issue) 1 report the overall efficacy and safety of tolvaptan in raising and maintaining serum sodium concentrations in patients with hyponatremia due to various causes. However, they do not report whether the primary end points were achieved in each of...

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Bibliographic Details
Published inThe New England journal of medicine Vol. 356; no. 9; pp. 961 - 963
Main Authors Weise, Wolfgang J, Rimmer, Jeffrey M, Hood, Virginia L
Format Journal Article
LanguageEnglish
Published United States Massachusetts Medical Society 01.03.2007
Subjects
Antidiuretic Hormone Receptor Antagonists
Benzazepines - therapeutic use
Heart Failure - complications
Humans
Hyponatremia - drug therapy
Hyponatremia - etiology
Inappropriate ADH Syndrome - complications
Liver Cirrhosis - complications
Patient Dropouts
Water-Electrolyte Balance
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Summary:To the Editor: Schrier and colleagues (Nov. 16 issue) 1 report the overall efficacy and safety of tolvaptan in raising and maintaining serum sodium concentrations in patients with hyponatremia due to various causes. However, they do not report whether the primary end points were achieved in each of the subgroups (patients with the syndrome of inappropriate antidiuretic hormone secretion [SIADH], those with liver cirrhosis, and those with chronic heart failure), although a previous preliminary report suggests that this treatment results in differences in the resolution of hyponatremia among these groups. 2 Furthermore, little mention is made about whether the treatment groups were . . .
Bibliography:SourceType-Other Sources-1
content type line 63
ObjectType-Correspondence-1
ObjectType-Commentary-2
ISSN:0028-4793
1533-4406
DOI:10.1056/NEJMc063545