The Incidence of Septic Pulmonary Embolism in Patients with Klebsiella pneumoniae Liver Abscess: A Systematic Review and Meta-analysis

Background: Septic pulmonary embolism (SPE) is an associated complication of Klebsiella pneumoniae liver abscess (KPLA). However, previous studies have reported that its incidence varies widely. We conducted a systematic review and meta-analysis to investigate the incidence of SPE in patients with K...

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Published inGastroenterology research and practice Vol. 2022; pp. 1 - 8
Main Authors Wang, Yunan, Wang, Hairui, Liu, Zhaoyu, Chang, Zhihui
Format Journal Article
LanguageEnglish
Published Egypt Hindawi 15.04.2022
John Wiley & Sons, Inc
Wiley
Subjects
Abscesses
Bacterial pneumonia
Care and treatment
Diabetes
Diabetics
Health aspects
Liver
Liver diseases
Males
Medical diagnosis
Medical research
Medicine, Experimental
Meta-analysis
Mortality
Pneumonia
Pulmonary embolism
Pulmonary embolisms
Review
Systematic review
South Korea
Singapore
China
Taiwan
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Summary:Background: Septic pulmonary embolism (SPE) is an associated complication of Klebsiella pneumoniae liver abscess (KPLA). However, previous studies have reported that its incidence varies widely. We conducted a systematic review and meta-analysis to investigate the incidence of SPE in patients with KPLA. We further analyzed their clinical and computed tomography (CT) features. Methods: Two researchers reviewed PubMed, EMBASE, Web of Science, and Cochrane Library databases to identify the articles that reported SPE in patients with KPLA. The search was conducted from the date of establishment of each database up to January 2021. After screening the articles and extracting the data, we used Review Manager 5.3 for analysis and processing. Results: We selected six articles that included 1,158 patients with KPLA. Of these, 70 patients had SPE. The pooled incidence of SPE was 6% (95% confidence interval, 3%–9%). Among patients with SPE, 85% were men, 72% had diabetes, and 52% displayed the feeding vessel sign on the chest CT. The mortality rate was 12%. Quality assessment revealed that half of the included studies had a high quality. Conclusion: The pooled incidence of SPE in patients with KPLA was 6%. Men and patients with diabetes were more prone to SPE. For patients with KPLA who had SPE as an associated complication, the mortality rate was approximately 12%.
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Academic Editor: Tatsuya Toyokawa
ISSN:1687-6121
1687-630X
DOI:10.1155/2022/3777122