Effects of long-term oral administration of ketoprofen in clinically healthy beagle dogs

• Published in: Journal of Veterinary Medical Science Vol. 67; no. 9; pp. 847 - 853
• Main Authors: Narita, T.(Gifu Univ. (Japan)), Tomizawa, N, Sato, R, Goryo, M, Hara, S
• Format: Journal Article
• Language: English
• Published: Japan JAPANESE SOCIETY OF VETERINARY SCIENCE 01.09.2005; Japan Science and Technology Agency
• Subjects: adverse effect; Animals; ANTI-INFLAMMATOIRE; Anti-Inflammatory Agents, Non-Steroidal - adverse effects; Anti-Inflammatory Agents, Non-Steroidal - toxicity; ANTIINFLAMMATORY AGENTS; ANTINFLAMATORIOS; APPAREIL DIGESTIF; Bleeding Time - veterinary; canine; CHIEN; DIGESTIVE SYSTEM; Dog Diseases - chemically induced; DOGS; EFECTOS SECUNDARIOS; EFFET SECONDAIRE; Feces - chemistry; Female; Gastroscopy - veterinary; Hemorrhage - chemically induced; Hemorrhage - veterinary; Ketoprofen; Ketoprofen - adverse effects; Ketoprofen - toxicity; Kidney - drug effects; KIDNEYS; long-term administration; Male; PERRO; PLATELETS; Pyloric Antrum - drug effects; REIN; RINONES; SIDE EFFECTS; SISTEMA DIGESTIVO; Stomach Diseases - chemically induced; Stomach Diseases - veterinary; THROMBOCYTE; TROMBOCITOS; Urinalysis - veterinary
• ISSN: 0916-7250; 1347-7439
• DOI: 10.1292/jvms.67.847

To investigate the adverse effects of long-term administration of ketoprofen in dogs, ketoprofen (1 mg/kg) was administered to five clinically healthy beagle dogs (ketoprofen group) and gelatin capsules (control group) were administered to four clinically healthy beagle dogs for 30 days. We monitored the dogs through periodic physical examination, blood analyses, endoscopic examinations, fecal occult blood tests, renal function tests, urinalysis, urinary enzyme indices and cuticle bleeding time analysis. The lesions in the stomach, especially in the pyloric antrum, and fecal occult blood progressively worsened in the ketoprofen group. However, the differences between the ketoprofen group and the control group were not statistically significant. One dog in the ketoprofen group temporarily exhibited a decrease in renal plasma flow and two dogs exhibited enzymuria. However, these changes did not persist and the other examinations showed no significant difference between premedication and postmedication in the ketoprofen group. Therefore, the adverse effects of long-term administration of ketoprofen observed in this study were not clinically important in healthy dogs. Nevertheless, further investigation of adverse renal effects from long-term administration of ketoprofen is necessary in the dogs with subclinical renal disease.