Detection of anti-ebolavirus antibodies in Ghanaian pigs

Some filoviruses such as ebolaviruses and marburgviruses, cause hemorrhagic fever in humans and nonhuman primates. Pigs are suggested to play a potential role in the filovirus ecology. We investigated the seroprevalence of filovirus infection in pigs in Ghana. Using a viral glycoprotein (GP)-based e...

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Published inJournal of Veterinary Medical Science Vol. 84; no. 11; pp. 1491 - 1494
Main Authors OGAWA, Hirohito, OHYA, Kenji, AYIZANGA, Raphael, MIYAMOTO, Hiroko, SHIGENO, Asako, YAMADA, Masao, TAKASHIMA, Yasuhiro, INOUE-MURAYAMA, Miho, TAKADA, Ayato, KAYANG, Boniface BABOREKA
Format Journal Article
LanguageEnglish
Published Tokyo JAPANESE SOCIETY OF VETERINARY SCIENCE 2022
Japan Science and Technology Agency
The Japanese Society of Veterinary Science
Subjects
antibody
ebolavirus
Enzyme-linked immunosorbent assay
Filoviridae
filovirus
Ghana
Hemorrhage
Hemorrhagic fever
Immunoglobulin G
pig
Serology
Virology
Western blotting
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Summary:Some filoviruses such as ebolaviruses and marburgviruses, cause hemorrhagic fever in humans and nonhuman primates. Pigs are suggested to play a potential role in the filovirus ecology. We investigated the seroprevalence of filovirus infection in pigs in Ghana. Using a viral glycoprotein (GP)-based enzyme-linked immunosorbent assay, we detected filovirus-specific immunoglobulin G antibodies in 5 of 139 samples. These positive sera showed specificities to four different filovirus species. Particularly, two of the positive sera reacted to GPs of two African ebolaviruses (i.e., Ebola virus and Taï Forest virus) in Western blotting. Our results suggest that these Ghanaian pigs were exposed to multiple filoviruses and emphasize the importance of continuous monitoring of filovirus infection in pig populations in West African countries.
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These authors contributed equally to this work.
ISSN:0916-7250
1347-7439
1347-7439
DOI:10.1292/jvms.22-0186