Synthesis of 2,2-difunctionalized 2 H -azirines via I 2 -mediated annulation of enamines

Various 2,2-difunctionalized 2 -azirines were synthesized I -mediated annulation reactions of readily accessible enamines in the presence of nitrogen or non-nitrogen nucleophiles. The features of the present synthesis process also include no use of transition metals, simple operation, mild reaction...

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Bibliographic Details
Published inOrganic & biomolecular chemistry Vol. 22; no. 11; pp. 2292 - 2299
Main Authors Lu, Qing, He, Yanmin, Chang, Junbiao, Yu, Wenquan
Format Journal Article
LanguageEnglish
Published England 13.03.2024
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Summary:Various 2,2-difunctionalized 2 -azirines were synthesized I -mediated annulation reactions of readily accessible enamines in the presence of nitrogen or non-nitrogen nucleophiles. The features of the present synthesis process also include no use of transition metals, simple operation, mild reaction conditions, a broad substrate scope, and gram-scale synthesis.
ISSN:1477-0520
1477-0539
DOI:10.1039/D4OB00156G