Risk of metabolic complications in the new PCOS phenotypes based on the Rotterdam criteria

• Published in: Fertility and sterility Vol. 88; no. 5; pp. 1389 - 1395
• Main Authors: Shroff, Rupal, Syrop, Craig H., Davis, William, Van Voorhis, Bradley J., Dokras, Anuja
• Format: Journal Article
• Language: English
• Published: New York, NY Elsevier Inc 01.11.2007; Elsevier Science
• Subjects: Adolescent; Adult; Biological and medical sciences; Female; Female genital diseases; Gynecology. Andrology. Obstetrics; Humans; Internal Medicine; Medical sciences; Metabolic Syndrome - diagnosis; Metabolic Syndrome - epidemiology; Metabolic Syndrome - genetics; Metabolic Syndrome - metabolism; Middle Aged; Non tumoral diseases; Obstetrics and Gynecology; Phenotype; Polycystic Ovary Syndrome - diagnosis; Polycystic Ovary Syndrome - epidemiology; Polycystic Ovary Syndrome - genetics; Polycystic Ovary Syndrome - metabolism; Prevalence; Retrospective Studies; Risk Factors; Gynecology; Female sterility; Risk; Polycystic ovary; Metabolism; Epidemiology; Obstetrics; Female genital diseases; Ovarian diseases; Phenotype; Criterion; Cyst; Risk factor; Complication; Benign neoplasm
• ISSN: 0015-0282; 1556-5653; 1556-5653
• DOI: 10.1016/j.fertnstert.2007.01.032

To determine the risk of metabolic complications, primarily metabolic syndrome, in all polycystic ovary syndrome (PCOS) phenotypes compared with control subjects. Retrospective chart review. University practice. Women with PCOS (Rotterdam definition; n = 258) and women without PCOS seen during the same time period for an annual exam used as controls (n = 110). None. Metabolic syndrome. Three PCOS phenotypes had a significantly higher prevalence of metabolic syndrome compared with the control subjects: oligomenorrhea/oligo-ovulation (O) + hyperandrogenism (H) + polycystic ovaries (P), age-adjusted odds ratio [OR] 6.3 (95% confidence interval 2.1–18.9); O+H, OR 7.8 (2.2–27.5); and H+P, OR 8.2 (2.3–29.3). There was no significant difference in the prevalence of metabolic syndrome between women with O+P and control subjects, even in obese women. The prevalence of insulin resistance and glucose intolerance was not significantly different between POCS phenotypes The risk of metabolic syndrome may vary among the four phenotypes of PCOS based on the Rotterdam criteria. This new information may be of relevance in counseling women with PCOS although larger studies may be needed to validate our findings.