The Evolving Landscape of Immunotherapy in Uterine Cancer: A Comprehensive Review

Endometrial cancer affects the uterus and is becoming increasingly common and deadly. Although surgery and adjuvant pelvic radiotherapy can often cure the disease when it is contained in the uterus, patients with metastatic or recurrent disease have limited response rates to chemotherapy, targeted a...

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Published inLife (Basel, Switzerland) Vol. 13; no. 7; p. 1502
Main Authors Hamoud, Bashar Haj, Sima, Romina Marina, Vacaroiu, Ileana Adela, Georgescu, Mihai-Teodor, Bobirca, Anca, Gaube, Alexandra, Bobirca, Florin, Georgescu, Dragos-Eugen
Format Journal Article
LanguageEnglish
Published Switzerland MDPI AG 01.07.2023
MDPI
Subjects
Breast cancer
Cancer
Cancer therapies
Chemotherapy
Development and progression
Disease
Drug therapy
Endometrial cancer
Endometrium
Estrogens
Fatalities
Forecasts and trends
Genomes
Health services
Immune system
Immunomodulation
Immunotherapy
Medical prognosis
Metastases
Mutation
Ovarian cancer
Radiation therapy
Review
Tumor microenvironment
Tumors
Uterine cancer
Uterus
Yeast
Romania
United States > US
endometrial cancer
immunotherapy
tumor microenvironment
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Summary:Endometrial cancer affects the uterus and is becoming increasingly common and deadly. Although surgery and adjuvant pelvic radiotherapy can often cure the disease when it is contained in the uterus, patients with metastatic or recurrent disease have limited response rates to chemotherapy, targeted agents, and hormonal therapy. To address this unmet clinical need, innovative treatment strategies are needed, and a growing focus on the immunomodulation of the tumor microenvironment has arisen. Current data suggest that active and/or passive immunotherapy may be promising for the treatment of endometrial cancer.
Bibliography:ObjectType-Article-2
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These authors contributed equally to this work.
ISSN:2075-1729
2075-1729
DOI:10.3390/life13071502