GABA and Dopamine Release from Different Brain Regions in Mice with Chronic Exposure to Organophosphate Methamidophos
Organophosphates such as methamidophos, usually used in the agricultural field, have harmful effects on humans. Exposures to insecticides has been associated with many disorders, including damage to the central and peripheral nervous system. Chronic exposure to organophosphates may lead to persisten...
Saved in:
Published in | Journal of Toxicologic Pathology Vol. 24; no. 3; pp. 163 - 168 |
---|---|
Main Authors | , , , , , , , |
Format | Journal Article |
Language | English |
Published |
Japan
JAPANESE SOCIETY OF TOXICOLOGIC PATHOLOGY
01.09.2011
Japan Science and Technology Agency The Japanese Society of Toxicologic Pathology |
Subjects | |
Online Access | Get full text |
Cover
Loading…
Summary: | Organophosphates such as methamidophos, usually used in the agricultural field, have harmful effects on humans. Exposures to insecticides has been associated with many disorders, including damage to the central and peripheral nervous system. Chronic exposure to organophosphates may lead to persistent neurological and neurobehavioral effects. This study was conducted to determine the effect of methamidophos on [3H]-dopamine (DA) and gamma aminobutyric acid (GABA) release from different brain regions after chronic exposure to it for 3, 6 or 9 months. After a six-month methamidophos treatment, the mice showed high susceptibility to convulsive seizures and a reduction in stimulated gamma aminobutyric acid release from the cerebral cortex and hippocampal slices, whereas stimulated (DA) release was slightly decreased from the striatum after three months of methamidophos exposure. The results indicate changes in gamma aminobutyric acid and dopamine neurotransmission, suggesting a specific neuronal damage. |
---|---|
Bibliography: | ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23 |
ISSN: | 0914-9198 1881-915X 1347-7404 |
DOI: | 10.1293/tox.24.163 |