Short-term psychological impact of the BRCA1/2 test result in women with breast cancer according to their perceived probability of genetic predisposition to cancer
Background: The effect of BRCA1/2 gene test result on anxiety, depression, cancer-related thought intrusion or avoidance and perceived control over cancer risk was assessed in breast cancer (BC) patients, according to their perceived probability of genetic predisposition to cancer. Methods: Two hund...
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Published in | British journal of cancer Vol. 108; no. 5; pp. 1012 - 1020 |
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Main Authors | , , , , , , , , , , , , |
Format | Journal Article |
Language | English |
Published |
London
Nature Publishing Group UK
19.03.2013
Nature Publishing Group Cancer Research UK |
Subjects | |
Online Access | Get full text |
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Summary: | Background:
The effect of
BRCA1/2
gene test result on anxiety, depression, cancer-related thought intrusion or avoidance and perceived control over cancer risk was assessed in breast cancer (BC) patients, according to their perceived probability of genetic predisposition to cancer.
Methods:
Two hundred and forty-three (89% response rate) women with BC completed questionnaires after an initial genetic counselling visit (T1), of which 180 (66%) completed questionnaires again after receiving the
BRCA1/2
results (T2). The discrepancy between women’s perceived probability of cancer genetic predisposition at T1 and the geneticist’s computed estimates was assessed.
Results:
In all, 74% of women received a negative uninformative (NU), 11% a positive
BRCA1/2
and 15% an unclassified variant (UV) result. On hierarchical regression analysis, in women with a positive
BRCA1/2
result (
vs
NU or UV), a lower perceived probability of cancer genetic predisposition than objective estimates at T1 predicted lower levels of anxiety at T2 (
β
=−0.28;
P
<0.01), whereas in women receiving a UV result (
vs
NU or positive
BRCA1/2
), a lower perceived probability of cancer genetic predisposition than objective estimates at T1 predicted higher levels of anxiety (
β
=0.20;
P
<0.01), depression (
β
=0.19;
P
<0.05) and intrusion (
β
=0.18;
P
<0.05) at T2.
Conclusion:
The type of
BRCA1/2
test result differently affects distress according to women’s perceived probability of genetic predisposition before testing. |
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Bibliography: | ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23 ObjectType-Article-2 ObjectType-Feature-1 PMCID: PMC3619058 |
ISSN: | 0007-0920 1532-1827 |
DOI: | 10.1038/bjc.2012.599 |