NF90 in posttranscriptional gene regulation and microRNA biogenesis

• Published in: International Journal of Molecular Sciences Vol. 14; no. 8; pp. 17111 - 17121
• Main Authors: Masuda, Kiyoshi, Kuwano, Yuki, Nishida, Kensei, Rokutan, Kazuhito, Imoto, Issei
• Format: Journal Article Book Review
• Language: English
• Published: Switzerland MDPI AG 19.08.2013; MDPI
• Subjects: Animals; double-stranded RNA binding proteins; Gene Expression Regulation, Neoplastic; Humans; microRNA biogenesis; MicroRNAs - biosynthesis; MicroRNAs - genetics; Neoplasms - genetics; Neoplasms - metabolism; NF90; Nuclear Factor 90 Proteins - physiology; posttranscriptional regulation; Protein Biosynthesis; Review; RNA Interference; RNA Stability; RNA, Messenger - genetics; RNA, Messenger - metabolism
• ISSN: 1422-0067; 1661-6596; 1422-0067
• DOI: 10.3390/ijms140817111

Gene expression patterns are effectively regulated by turnover and translation regulatory (TTR) RNA-binding proteins (RBPs). The TTR-RBPs control gene expression at posttranscriptional levels, such as pre-mRNA splicing, mRNA cytoplasmic export, turnover, storage, and translation. Double-stranded RNA binding proteins (DSRBPs) are known to regulate many processes of cellular metabolism, including transcriptional control, translational control, mRNA processing and localization. Nuclear factor 90 (NF90), one of the DSRBPs, is abundantly expressed in vertebrate tissue and participates in many aspects of RNA metabolism. NF90 was originally purified as a component of a DNA binding complex which binds to the antigen recognition response element 2 in the interleukin 2 promoter. Recent studies have provided us with interesting insights into its possible physiological roles in RNA metabolism, including transcription, degradation, and translation. In addition, it was shown that NF90 regulates microRNA expression. In this review, we try to focus on the function of NF90 in posttranscriptional gene regulation and microRNA biogenesis.