The Pathogenesis of Resection-Associated Intestinal Adaptation

• Published in: Cellular and molecular gastroenterology and hepatology Vol. 2; no. 4; pp. 429 - 438
• Main Author: Warner, Brad W
• Format: Journal Article
• Language: English
• Published: United States Elsevier Inc 01.07.2016; Elsevier
• Subjects: Absorption; Adaptation; Angiogenesis; Apoptosis; Epithelium; Gastroenterology and Hepatology; Growth Factors; Proliferation; Review; Villus; retinoblastoma protein; glucagon-like peptide-2; small-bowel bacterial overgrowth; insulin-like growth factor-1; Villus; small-bowel resection; Rb; Angiogenesis; Absorption; parenteral nutrition; lactate-accumulator; growth hormone; Adaptation; GH; SBR; Growth Factors; EGF; IGF-1; Proliferation; Epithelium; LA; SBBO; epidermal growth factor; GLP-2; PN; Apoptosis; EGF, epidermal growth factor; GH, growth hormone; PN, parenteral nutrition; SBBO, small-bowel bacterial overgrowth; LA, lactate-accumulator; Rb, retinoblastoma protein; IGF-1, insulin-like growth factor-1; SBR, small-bowel resection; GLP-2, glucagon-like peptide-2
• ISSN: 2352-345X; 2352-345X
• DOI: 10.1016/j.jcmgh.2016.05.001

After massive small-bowel resection, the remnant bowel compensates by a process termed adaptation . Adaptation is characterized by villus elongation and crypt deepening, which increases the capacity for absorption and digestion per unit length. The mechanisms/mediators of this important response are multiple. The purpose of this review is to highlight the major basic contributions in elucidating a more comprehensive understanding of this process.