Short Sleep Duration is Associated with Prolonged Virus Shedding in SARS-CoV-2 Omicron-Infected Patients

• Published in: Nature and science of sleep Vol. 15; pp. 547 - 554
• Main Authors: Lin, Ying Ni, Zhou, Li Na, Liu, Zhuo Ran, Wang, Yi, Li, Shi Qi, Lu, Fang Ying, Zhang, Liu, Li, Qing Yun
• Format: Journal Article
• Language: English
• Published: New Zealand Dove Medical Press Limited 31.07.2023; Dove; Dove Medical Press
• Subjects: Analysis; Antiviral agents; Coronaviruses; covid-19 pandemic; Health aspects; Original Research; Prognosis; sars-cov-2 omicron; Severe acute respiratory syndrome; Sleep disorders; sleep duration; China; COVID-19 pandemic; SARS-CoV-2 Omicron; sleep duration
• ISSN: 1179-1608; 1179-1608
• DOI: 10.2147/NSS.S411677

Sleep disturbance has been implicated in poor prognosis of coronavirus disease 2019 (COVID-19), but less is known about the influence of short sleep duration on COVID-19 outcomes. We aim to investigate whether short sleep duration is associated with prolonged virus shedding duration in severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) Omicron-infected patients. A total of 270 patients with a laboratory confirmed COVID-19 diagnosis during SARS-CoV-2 Omicron-predominant period were recruited. Self-reported sleep duration of the patients was collected. The two-way analysis of variance (ANOVA) was used to determine the interactions between sleep duration and variables, and multivariate logistic regression analysis was used to analyze the effect of independent variables on longer virus shedding duration. The two-way ANOVA revealed a significant sleep duration × snoring interaction effect for virus shedding duration, and a sleep duration × sex interaction effect for virus shedding duration. Multivariate logistic regression model illustrated that patients sleeping <6 h were at greater risk of prolonged virus shedding duration compared to those sleeping ≥6 hours (OR = 1.80, 95% CI = 1.01-3.26), independent of age, sex, co-existing diseases, vaccination condition, and antiviral treatment. Short sleep duration (<6 h) was associated with increased virus shedding in SARS-CoV-2 Omicron-infected patients.