Mechanisms and Therapeutic Potential of GPX4 in Pain Modulation

• Published in: Pain and therapy Vol. 14; no. 1; pp. 21 - 45
• Main Authors: Fan, Shiwen, Wang, Kaixin, Zhang, Tianhao, Deng, Daling, Shen, Jiwei, Zhao, Bowen, Fu, Daan, Chen, Xiangdong
• Format: Journal Article
• Language: English
• Published: Cheshire Springer Healthcare 01.02.2025; Adis, Springer Healthcare
• Subjects: Glutathione peroxidase 4; Internal Medicine; Mechanisms; Medicine; Medicine & Public Health; Oxidative stress; Pain Medicine; Pain regulation; Review; Oxidative stress; Mechanisms; Pain regulation; Glutathione peroxidase 4

Pain, a complex symptom encompassing both sensory and emotional dimensions, constitutes a significant global public health issue. Oxidative stress is a pivotal factor in the complex pathophysiology of pain, with glutathione peroxidase 4 (GPX4) recognized as a crucial antioxidant enzyme involved in b...