Mechanisms and Therapeutic Potential of GPX4 in Pain Modulation

Pain, a complex symptom encompassing both sensory and emotional dimensions, constitutes a significant global public health issue. Oxidative stress is a pivotal factor in the complex pathophysiology of pain, with glutathione peroxidase 4 (GPX4) recognized as a crucial antioxidant enzyme involved in b...

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Published inPain and therapy Vol. 14; no. 1; pp. 21 - 45
Main Authors Fan, Shiwen, Wang, Kaixin, Zhang, Tianhao, Deng, Daling, Shen, Jiwei, Zhao, Bowen, Fu, Daan, Chen, Xiangdong
Format Journal Article
LanguageEnglish
Published Cheshire Springer Healthcare 01.02.2025
Adis, Springer Healthcare
Subjects
Glutathione peroxidase 4
Internal Medicine
Mechanisms
Medicine
Medicine & Public Health
Oxidative stress
Pain Medicine
Pain regulation
Review
Oxidative stress
Mechanisms
Pain regulation
Glutathione peroxidase 4
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Summary:Pain, a complex symptom encompassing both sensory and emotional dimensions, constitutes a significant global public health issue. Oxidative stress is a pivotal factor in the complex pathophysiology of pain, with glutathione peroxidase 4 (GPX4) recognized as a crucial antioxidant enzyme involved in both antioxidant defense mechanisms and ferroptosis pathways. This review systematically explores GPX4’s functions across various pain models, including neuropathic, inflammatory, low back, and cancer-related pain. Specifically, the focus includes GPX4’s physiological roles, antioxidant defense mechanisms, regulation of ferroptosis, involvement in signal transduction pathways, and metabolic regulation. By summarizing current research, we highlight the potential of GPX4-targeted therapies in pain management.
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ISSN:2193-8237
2193-651X
DOI:10.1007/s40122-024-00673-8