An Amphiphile-Lipase Aggregate Bearing 1, 2-Dialkylated Mannitol Ether as a New Type of Immobilized Enzyme in Organic Solvents

• Published in: Chemical & pharmaceutical bulletin Vol. 45; no. 12; pp. 2085 - 2088
• Main Authors: AKITA, Hiroyuki, KATO, Keisuke, UMEZAWA, Isao, MATSUKURA, Hiroko
• Format: Journal Article
• Language: English
• Published: TOKYO The Pharmaceutical Society of Japan 1997; Pharmaceutical Soc Japan; Maruzen; Japan Science and Technology Agency
• Subjects: amphiphile-lipase aggregate; Bioconversions. Hemisynthesis; Biological and medical sciences; Biotechnology; Chemistry; Chemistry, Medicinal; Chemistry, Multidisciplinary; enantioselective acetylation; enantioselective hydrolysis; Fundamental and applied biological sciences. Psychology; Life Sciences & Biomedicine; Methods. Procedures. Technologies; Pharmacology & Pharmacy; Physical Sciences; Science & Technology; thioindolmycin; α-acetoxy ester; alpha-acetoxy ester; enantioselective acetylation; enantioselective hydrolysis; thioindolmycin; amphiphile-lipase aggregate; Enantioselectivity; Hydroxyester; Enzyme; Triacylglycerol lipase; Esterases; Amphiphilic compound; Carboxylic ester hydrolases; Hydrolysis; Organic solvent; Alditol; Hydroxyether; Hydrolases; Acetylation; Polyol; Immobilized enzyme; Enzymatic reaction
• ISSN: 0009-2363; 1347-5223
• DOI: 10.1248/cpb.45.2085

Neutral amphiphiles of a new type corresponding to 1, 2-dialkylated mannitol ethers (6-10) were synthesized. Amephiphile-lipase aggregates were found to function as an immobilized enzyme system for enantioselective acetylation or enantioselective hydrolysis of α-hydroxy esters or α-acetoxy esters, respectively, in organic solvents.