KatA, the Major Catalase, Is Critical for Osmoprotection and Virulence in Pseudomonas aeruginosa PA14

We demonstrate that among the three monofunctional catalases of Pseudomonas aeruginosa PA14, KatA and, to a lesser extent, KatB, but not KatE, are required for resistance to peroxide and osmotic stresses. KatA is crucial for adaptation to H₂O₂ stress and full virulence in both Drosophila melanogaste...

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Published inInfection and Immunity Vol. 73; no. 7; pp. 4399 - 4403
Main Authors Lee, Ji-Sun, Heo, Yun-Jeong, Lee, Jeong K, Cho, You-Hee
Format Journal Article
LanguageEnglish
Published Washington, DC American Society for Microbiology 01.07.2005
Subjects
Animals
Bacteriology
Biological and medical sciences
Catalase - physiology
Drosophila melanogaster - microbiology
Fundamental and applied biological sciences. Psychology
Hydrogen Peroxide - pharmacology
Microbiology
Miscellaneous
Molecular Pathogenesis
Potassium Chloride - pharmacology
Pseudomonas aeruginosa - drug effects
Pseudomonas aeruginosa - enzymology
Pseudomonas aeruginosa - pathogenicity
Virulence
Pseudomonadales
Peroxidases
Catalase
Microbiology
Enzyme
Virulence
Bacteria
Pseudomonadaceae
Pseudomonas aeruginosa
Oxidoreductases
Immunity
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Summary:We demonstrate that among the three monofunctional catalases of Pseudomonas aeruginosa PA14, KatA and, to a lesser extent, KatB, but not KatE, are required for resistance to peroxide and osmotic stresses. KatA is crucial for adaptation to H₂O₂ stress and full virulence in both Drosophila melanogaster and mice. This dismantling of catalase roles represents a specialized catalytic system primarily involving KatA in responses to adverse environmental conditions.
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Editor: V. J. DiRita
Corresponding author. Mailing address: Department of Life Science, Sogang University, Seoul 121-742, Korea. Phone: 82-2-705-8793. Fax: 82-2-704-3601. E-mail: youhee@sogang.ac.kr.
ISSN:0019-9567
1098-5522
DOI:10.1128/IAI.73.7.4399-4403.2005