The clinical utilization of circulating cell free DNA (CCFDNA) in blood of cancer patients

Qualitative and quantitative testing of circulating cell free DNA (CCFDNA) can be applied for the management of malignant and benign neoplasms. Detecting circulating DNA in cancer patients may help develop a DNA profile for early stage diagnosis in malignancies. The technical issues of obtaining, us...

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Published inInternational Journal of Molecular Sciences Vol. 14; no. 9; pp. 18925 - 18958
Main Authors Elshimali, Yahya I, Khaddour, Husseina, Sarkissyan, Marianna, Wu, Yanyuan, Vadgama, Jaydutt V
Format Journal Article Book Review
LanguageEnglish
Published Switzerland MDPI AG 13.09.2013
MDPI
Subjects
circulating cell free DNA
DNA - blood
DNA Methylation
early diagnosis
follow up on cancer treatment
Humans
Loss of Heterozygosity
Microsatellite Instability
Multiplex Polymerase Chain Reaction
neoplasms
Neoplasms - blood
Neoplasms - diagnosis
Neoplasms - genetics
prognosis
Review
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Summary:Qualitative and quantitative testing of circulating cell free DNA (CCFDNA) can be applied for the management of malignant and benign neoplasms. Detecting circulating DNA in cancer patients may help develop a DNA profile for early stage diagnosis in malignancies. The technical issues of obtaining, using, and analyzing CCFDNA from blood will be discussed.
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These authors contributed equally to this work.
ISSN:1422-0067
1661-6596
1422-0067
DOI:10.3390/ijms140918925