Causal association of sleep traits with the risk of thyroid cancer: A mendelian randomization study

• Published in: BMC cancer Vol. 24; no. 1; p. 605
• Main Authors: Zong, Liang, Liu, Guiping, He, Hongsheng, Huang, Deliang
• Format: Journal Article
• Language: English
• Published: England BioMed Central Ltd 17.05.2024; BioMed Central; BMC
• Subjects: Biobanks; Cancer; Confounding (Statistics); Gene polymorphism; Genetic Predisposition to Disease; Genome-wide association studies; Genome-Wide Association Study; Genomes; Genomics; Health aspects; Humans; Insomnia; Mendelian randomization; Mendelian Randomization Analysis; Oncology, Experimental; Phenotypes; Pleiotropy; Polymorphism, Single Nucleotide; Quality control; Risk Factors; Single nucleotide polymorphism; Single nucleotide polymorphisms; Sleep; Sleep disorders; Sleep traits; Sleep Wake Disorders - complications; Sleep Wake Disorders - epidemiology; Sleep Wake Disorders - genetics; Sleep-wake cycle; Thyroid cancer; Thyroid Neoplasms - epidemiology; Thyroid Neoplasms - genetics; Finland; China; United Kingdom > UK; Sleep traits; Thyroid cancer; Mendelian randomization; Single nucleotide polymorphism
• ISSN: 1471-2407; 1471-2407
• DOI: 10.1186/s12885-024-12376-6

This study was to explore the causal associations of sleep traits including sleep duration, snoring, chronotype, sleep disorders, getting up in the morning, sleeplessness/insomnia and nap during day with the risk of thyroid cancer based on Mendelian randomization (MR) analysis. Summary single nucleotide polymorphism (SNP)-phenotype association data were obtained from published genome-wide association studies (GWASs) using the FinnGen and UK Biobank databases. A series of screening processes were performed to select qualified SNPs strongly related to exposure. We applied the inverse variance weighted (IVW), the Mendelian Randomization robust adjusted profile score (MR-RAPS), the Mendelian randomization pleiotropy residual sum and outlier (MR-PRESSO), and the Weighted Median to estimate the causal links between sleep traits and the risk of thyroid cancer. Odds ratio (OR) and 95% confidence interval (CI) were calculated. The IVW results showed that getting up in the morning (OR = 0.055, 95%CI: 0.004-0.741) and napping during day (OR = 0.031, 95%CI: 0.002-0.462) were associated with decreased risk of thyroid cancer in the Italian population. A 1.30-h decrease of sleep duration was associated with 7.307-fold of thyroid cancer risk in the Finnish population (OR = 7.307, 95%CI: 1.642-32.519). Cronotype could decrease the risk of thyroid cancer in the Finnish population (OR = 0.282, 95%CI: 0.085-0.939). Sleep disorders increased the risk of thyroid cancer in the Finnish population (OR = 2.298, 95%CI: 1.194-4.422). The combined results revealed that sleep duration was correlated with increased risk of thyroid cancer (OR = 5.600, 95%CI: 1.458-21.486). Decreased sleep duration was associated with increased risk of thyroid cancer, which indicated the importance of adequate sleep for the prevention of thyroid cancer.