ALTERATIONS IN THE SYNTHESES OF RNA AND DNA BY CHROMIUM (III) IN REGENERATING RAT LIVER

The administration of trivalent chromium (Cr (III)) caused a significant enhancement of RNA synthesis in rat liver after partial hepatectomy. Cr was accumulated in the liver cell nuclei and concentrated in the nucleoli. Of RNAs synthesized in the nuclei, nucleolar RNA synthesis was most enhanced by...

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Published inChemical & pharmaceutical bulletin Vol. 30; no. 9; pp. 3439 - 3441
Main Authors Okada, Shoji, Ohba, Hiroshi, Suzuki, Mizue, Tsukada, Hideo
Format Journal Article
LanguageEnglish
Published Japan The Pharmaceutical Society of Japan 01.01.1982
Subjects
Animals
Chromium - pharmacology
DNA - biosynthesis
DNA synthesis
Liver - drug effects
Liver - metabolism
Liver Regeneration
Male
Rats
Rats, Inbred Strains
RNA - biosynthesis
Online AccessGet full text
ISSN0009-2363
1347-5223
DOI10.1248/cpb.30.3439

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Abstract The administration of trivalent chromium (Cr (III)) caused a significant enhancement of RNA synthesis in rat liver after partial hepatectomy. Cr was accumulated in the liver cell nuclei and concentrated in the nucleoli. Of RNAs synthesized in the nuclei, nucleolar RNA synthesis was most enhanced by the administration of Cr (III). Furthermore, DNA synthesis in the Cr (III)-administered rat liver after partial hepatectomy was initiated a little earlier and was less synchronized than in control rats.
AbstractList The administration of trivalent chromium (CR (III)) caused a significant enhancement of RNA synthesis in rat liver after partial hepatectomy. Cr was accumulated in the liver cell nuclei and concentrated in the nucleoli. Of RNAs synthesized in the nuclei, nucleolar RNA synthesis was most enhanced by the administration of Cr (III). Furthermore, DNA synthesis in the Cr (III)-administered rat liver after partial hepatectomy was initiated a little earlier and was less synthronized than in control rats.
The administration of trivalent chromium (Cr (III)) caused a significant enhancement of RNA synthesis in rat liver after partial hepatectomy. Cr was accumulated in the liver cell nuclei and concentrated in the nucleoli. Of RNAs synthesized in the nuclei, nucleolar RNA synthesis was most enhanced by the administration of Cr (III). Furthermore, DNA synthesis in the Cr (III)-administered rat liver after partial hepatectomy was initiated a little earlier and was less synchronized than in control rats.
Author Ohba, Hiroshi
Okada, Shoji
Suzuki, Mizue
Tsukada, Hideo
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– reference: 5) H. Ono, H. Matsui, A. Yamamoto, T. Ono, and O. Wada, Jpn. J. Hyg., 35, 188 (1980).
– reference: 3) S. Okada, H. Ohba, and M. Taniyama, J. Inorg. Biochem., 15, 223 (1981);
– reference: 6) J. W. Grisham, Cancer Res., 22, 842 (1962);
– reference: A. Levis, M. Buttignol, V. Bianchi, and G. Sponza, Cancer Res., 38, 110 (1978).
– reference: N. L. R. Bucher, M. N. Swaffield, and J. F. DiTroia, Cancer Res., 24, 509 (1964).
– reference: 1) K. Schwartz and W. Mertz, Arch. Biochem. Biophys., 85, 292 (1959);
– reference: 7) G. M. Higgins and R. M. Anderson, Arch. Pathol., 12, 186 (1931).
– reference: S. Okada, M. Taniyama, and H. Ohba, J. Inorg. Biochem., 17, 41 (1982).
– reference: 9) K. Tsukada and I. Lieberman, J. Biol. Chem., 239, 1564 (1964).
– reference: 2) A. Léonard and R. R. Lauwerys, Mutation Res., 76, 227 (1980).
– reference: 4) S. Okada, M. Suzuki, and H. Ohba, J. Inorg. Biochem., submitted.
– reference: 10) I. Lieberman, "Biochemistry of Cell Division," ed. by R. Baserga, Charles C. Thomas Publisher, Springfield, 1969, p. 119; K. Tsukada, Metabolism and Disease, 19, 153 (1982).
– reference: W. Mertz, Science, 213, 1332 (1982).
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Snippet The administration of trivalent chromium (Cr (III)) caused a significant enhancement of RNA synthesis in rat liver after partial hepatectomy. Cr was...
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SubjectTerms Animals
Chromium - pharmacology
DNA - biosynthesis
DNA synthesis
Liver - drug effects
Liver - metabolism
Liver Regeneration
Male
Rats
Rats, Inbred Strains
RNA - biosynthesis
Title ALTERATIONS IN THE SYNTHESES OF RNA AND DNA BY CHROMIUM (III) IN REGENERATING RAT LIVER
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