ALTERATIONS IN THE SYNTHESES OF RNA AND DNA BY CHROMIUM (III) IN REGENERATING RAT LIVER

The administration of trivalent chromium (Cr (III)) caused a significant enhancement of RNA synthesis in rat liver after partial hepatectomy. Cr was accumulated in the liver cell nuclei and concentrated in the nucleoli. Of RNAs synthesized in the nuclei, nucleolar RNA synthesis was most enhanced by...

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Published inChemical & pharmaceutical bulletin Vol. 30; no. 9; pp. 3439 - 3441
Main Authors Okada, Shoji, Ohba, Hiroshi, Suzuki, Mizue, Tsukada, Hideo
Format Journal Article
LanguageEnglish
Published Japan The Pharmaceutical Society of Japan 01.01.1982
Subjects
Animals
Chromium - pharmacology
DNA - biosynthesis
DNA synthesis
Liver - drug effects
Liver - metabolism
Liver Regeneration
Male
Rats
Rats, Inbred Strains
RNA - biosynthesis
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ISSN0009-2363
1347-5223
DOI10.1248/cpb.30.3439

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Summary:The administration of trivalent chromium (Cr (III)) caused a significant enhancement of RNA synthesis in rat liver after partial hepatectomy. Cr was accumulated in the liver cell nuclei and concentrated in the nucleoli. Of RNAs synthesized in the nuclei, nucleolar RNA synthesis was most enhanced by the administration of Cr (III). Furthermore, DNA synthesis in the Cr (III)-administered rat liver after partial hepatectomy was initiated a little earlier and was less synchronized than in control rats.
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ISSN:0009-2363
1347-5223
DOI:10.1248/cpb.30.3439