Severe hypertriglyceridemia-induced acute pancreatitis: Successful management by plasmapheresis

The blood was highly lipemic [Figure 1] with serum triglyceride (TG) level of 6800 mg/dl, total cholesterol of 613 mg/dl, low-density lipoprotein cholesterol of 137 mg/dl, and high-density lipoprotein cholesterol of 53 mg/dl. A proposed mechanism is hydrolysis of TG by pancreatic lipase, leading to...

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Published inIndian journal of nephrology Vol. 29; no. 3; pp. 217 - 219
Main Authors Ramesh, B. N. R, Raju, S, Surendra, M, Prasad, K, Krishna, V
Format Journal Article
LanguageEnglish
Published India Wolters Kluwer India Pvt. Ltd 01.05.2019
Medknow Publications and Media Pvt. Ltd
Scientific Scholar
Wolters Kluwer - Medknow
Subjects
Abdomen
Cholesterol
Insulin
Letters to Editor
Pancreatitis
Atlanta Georgia
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Summary:The blood was highly lipemic [Figure 1] with serum triglyceride (TG) level of 6800 mg/dl, total cholesterol of 613 mg/dl, low-density lipoprotein cholesterol of 137 mg/dl, and high-density lipoprotein cholesterol of 53 mg/dl. A proposed mechanism is hydrolysis of TG by pancreatic lipase, leading to accumulation of high concentrations free fatty acids and chylomicrons which can produce acinar cell injury and capillary plugging causing ischemia and acidosis activating trypsinogen and AP. The beneficial effect of plasmapheresis is believed to be because of rapid decrease in TG levels; however, removal of excessive proteases from the plasma which are key enzymes in inflammation and replacement of consumed protease inhibitors might be an additional benefit.
Bibliography:ObjectType-Article-1
SourceType-Scholarly Journals-1
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ISSN:0971-4065
1998-3662
DOI:10.4103/ijn.IJN_241_17