ROLE of exercise in maintaining the integrity of the neuromuscular junction

ABSTRACT Physical activity plays an important role in preventing chronic disease in adults and the elderly. Exercise has beneficial effects on the nervous system, including at the neuromuscular junction (NMJ). Exercise causes hypertrophy of NMJs and improves recovery from peripheral nerve injuries,...

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Published inMuscle & nerve Vol. 49; no. 3; pp. 315 - 324
Main Authors Nishimune, Hiroshi, Stanford, John A., Mori, Yasuo
Format Journal Article
LanguageEnglish
Published United States Blackwell Publishing Ltd 01.03.2014
Wiley Subscription Services, Inc
Subjects
active zone
aging
Aging - physiology
Animals
Exercise
Exercise - physiology
Humans
laminin
Muscular system
Nerve Tissue Proteins - metabolism
Neuregulin-1 - metabolism
Neuromuscular Junction - metabolism
Neuromuscular Junction - physiology
Physical fitness
PPAR gamma - metabolism
synapse
exercise
laminin
aging
synapse
active zone
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Abstract ABSTRACT Physical activity plays an important role in preventing chronic disease in adults and the elderly. Exercise has beneficial effects on the nervous system, including at the neuromuscular junction (NMJ). Exercise causes hypertrophy of NMJs and improves recovery from peripheral nerve injuries, whereas decreased physical activity causes degenerative changes in NMJs. Recent studies have begun to elucidate molecular mechanisms underlying the beneficial effects of exercise. These mechanisms involve Bassoon, neuregulin‐1, peroxisome proliferator–activated receptor gamma coactivator 1α, insulin‐like growth factor‐1, glial cell line–derived neurotrophic factor, neurotrophin 4, Homer, and nuclear factor of activated T cells c1. For example, NMJ denervation and active zone decreases have been observed in aged NMJs, but these age‐dependent degenerative changes can be ameliorated by exercise. In this review we assess the effects of exercise on the maintenance and regeneration of NMJs and highlight recent insights into the molecular mechanisms underlying these exercise effects. Muscle Nerve 49:315–324, 2014
AbstractList ABSTRACT Physical activity plays an important role in preventing chronic disease in adults and the elderly. Exercise has beneficial effects on the nervous system, including at the neuromuscular junction (NMJ). Exercise causes hypertrophy of NMJs and improves recovery from peripheral nerve injuries, whereas decreased physical activity causes degenerative changes in NMJs. Recent studies have begun to elucidate molecular mechanisms underlying the beneficial effects of exercise. These mechanisms involve Bassoon, neuregulin‐1, peroxisome proliferator–activated receptor gamma coactivator 1α, insulin‐like growth factor‐1, glial cell line–derived neurotrophic factor, neurotrophin 4, Homer, and nuclear factor of activated T cells c1. For example, NMJ denervation and active zone decreases have been observed in aged NMJs, but these age‐dependent degenerative changes can be ameliorated by exercise. In this review we assess the effects of exercise on the maintenance and regeneration of NMJs and highlight recent insights into the molecular mechanisms underlying these exercise effects. Muscle Nerve 49 :315–324, 2014
Physical activity plays an important role in preventing chronic disease in adults and the elderly. Exercise has beneficial effects on the nervous system, including at the neuromuscular junction (NMJ). Exercise causes hypertrophy of NMJs and improves recovery from peripheral nerve injuries, whereas decreased physical activity causes degenerative changes in NMJs. Recent studies have begun to elucidate molecular mechanisms underlying the beneficial effects of exercise. These mechanisms involve Bassoon, neuregulin-1, peroxisome proliferator-activated receptor gamma coactivator 1α, insulin-like growth factor-1, glial cell line-derived neurotrophic factor, neurotrophin 4, Homer, and nuclear factor of activated T cells c1. For example, NMJ denervation and active zone decreases have been observed in aged NMJs, but these age-dependent degenerative changes can be ameliorated by exercise. In this review we assess the effects of exercise on the maintenance and regeneration of NMJs and highlight recent insights into the molecular mechanisms underlying these exercise effects.
Physical activity plays an important role in preventing chronic disease in adults and the elderly. Exercise has beneficial effects on the nervous system, including at the neuromuscular junction (NMJ). Exercise causes hypertrophy of NMJs and improves recovery from peripheral nerve injuries, whereas decreased physical activity causes degenerative changes in NMJs. Recent studies have begun to elucidate molecular mechanisms underlying the beneficial effects of exercise. These mechanisms involve Bassoon, neuregulin-1, peroxisome proliferator-activated receptor gamma coactivator 1α, Insulin-like growth factor-1, glial cell line-derived neurotrophic factor, neurotrophin 4, Homer, and nuclear factor of activated T cells c1. For example, NMJ denervation and active zone decreases have been observed in aged NMJs, but these age-dependent degenerative changes can be ameliorated by exercise. This review will discuss the effects of exercise on the maintenance and regeneration of NMJs and will highlight recent insights into the molecular mechanisms underlying these exercise effects.
ABSTRACT Physical activity plays an important role in preventing chronic disease in adults and the elderly. Exercise has beneficial effects on the nervous system, including at the neuromuscular junction (NMJ). Exercise causes hypertrophy of NMJs and improves recovery from peripheral nerve injuries, whereas decreased physical activity causes degenerative changes in NMJs. Recent studies have begun to elucidate molecular mechanisms underlying the beneficial effects of exercise. These mechanisms involve Bassoon, neuregulin‐1, peroxisome proliferator–activated receptor gamma coactivator 1α, insulin‐like growth factor‐1, glial cell line–derived neurotrophic factor, neurotrophin 4, Homer, and nuclear factor of activated T cells c1. For example, NMJ denervation and active zone decreases have been observed in aged NMJs, but these age‐dependent degenerative changes can be ameliorated by exercise. In this review we assess the effects of exercise on the maintenance and regeneration of NMJs and highlight recent insights into the molecular mechanisms underlying these exercise effects. Muscle Nerve 49:315–324, 2014
Physical activity plays an important role in preventing chronic disease in adults and the elderly. Exercise has beneficial effects on the nervous system, including at the neuromuscular junction (NMJ). Exercise causes hypertrophy of NMJs and improves recovery from peripheral nerve injuries, whereas decreased physical activity causes degenerative changes in NMJs. Recent studies have begun to elucidate molecular mechanisms underlying the beneficial effects of exercise. These mechanisms involve Bassoon, neuregulin-1, peroxisome proliferator-activated receptor gamma coactivator 1[alpha], insulin-like growth factor-1, glial cell line-derived neurotrophic factor, neurotrophin 4, Homer, and nuclear factor of activated T cells c1. For example, NMJ denervation and active zone decreases have been observed in aged NMJs, but these age-dependent degenerative changes can be ameliorated by exercise. In this review we assess the effects of exercise on the maintenance and regeneration of NMJs and highlight recent insights into the molecular mechanisms underlying these exercise effects. Muscle Nerve 49:315-324, 2014 [PUBLICATION ABSTRACT]
Physical activity plays an important role in preventing chronic disease in adults and the elderly. Exercise has beneficial effects on the nervous system, including at the neuromuscular junction (NMJ). Exercise causes hypertrophy of NMJs and improves recovery from peripheral nerve injuries, whereas decreased physical activity causes degenerative changes in NMJs. Recent studies have begun to elucidate molecular mechanisms underlying the beneficial effects of exercise. These mechanisms involve Bassoon, neuregulin-1, peroxisome proliferator-activated receptor gamma coactivator 1[alpha], insulin-like growth factor-1, glial cell line-derived neurotrophic factor, neurotrophin 4, Homer, and nuclear factor of activated T cells c1. For example, NMJ denervation and active zone decreases have been observed in aged NMJs, but these age-dependent degenerative changes can be ameliorated by exercise. In this review we assess the effects of exercise on the maintenance and regeneration of NMJs and highlight recent insights into the molecular mechanisms underlying these exercise effects. Muscle Nerve 49:315-324, 2014
Author Nishimune, Hiroshi
Stanford, John A.
Mori, Yasuo
AuthorAffiliation 2 Department of Molecular & Integrative Physiology, University of Kansas School of Medicine, Kansas City, KS, USA
3 Department of Synthetic Chemistry and Biological Chemistry, Graduate School of Engineering, Kyoto University, Katsura, Kyoto, Japan
1 Department of Anatomy and Cell Biology, University of Kansas School of Medicine, Kansas City, KS, USA
AuthorAffiliation_xml – name: 3 Department of Synthetic Chemistry and Biological Chemistry, Graduate School of Engineering, Kyoto University, Katsura, Kyoto, Japan
– name: 2 Department of Molecular & Integrative Physiology, University of Kansas School of Medicine, Kansas City, KS, USA
– name: 1 Department of Anatomy and Cell Biology, University of Kansas School of Medicine, Kansas City, KS, USA
Author_xml – sequence: 1
  givenname: Hiroshi
  surname: Nishimune
  fullname: Nishimune, Hiroshi
  email: hnishimune@kumc.edu
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– sequence: 2
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  givenname: Yasuo
  surname: Mori
  fullname: Mori, Yasuo
  organization: Department of Synthetic Chemistry and Biological Chemistry, Graduate School of Engineering, Kyoto University, Kyoto, Katsura, Japan
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Issue 3
Keywords exercise
laminin
aging
synapse
active zone
Language English
License Copyright © 2013 Wiley Periodicals, Inc.
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The work in our laboratories was supported by grants from the National Institutes of Health (1R01NS078214 to H.N., and AG023549 and AG026491 to J.A.S.), the Whitehall Foundation (to H.N), and the Japan Society for the Promotion of Science (to Y.M.). Core facility support was provided by the NIH‐NCRR (P20 RR024214) and NIH‐NICHD (HD02528).
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PublicationDate March 2014
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  year: 2014
  text: March 2014
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PublicationTitle Muscle & nerve
PublicationTitleAlternate Muscle Nerve
PublicationYear 2014
Publisher Blackwell Publishing Ltd
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Snippet ABSTRACT Physical activity plays an important role in preventing chronic disease in adults and the elderly. Exercise has beneficial effects on the nervous...
Physical activity plays an important role in preventing chronic disease in adults and the elderly. Exercise has beneficial effects on the nervous system,...
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SubjectTerms active zone
aging
Aging - physiology
Animals
Exercise
Exercise - physiology
Humans
laminin
Muscular system
Nerve Tissue Proteins - metabolism
Neuregulin-1 - metabolism
Neuromuscular Junction - metabolism
Neuromuscular Junction - physiology
Physical fitness
PPAR gamma - metabolism
synapse
Title ROLE of exercise in maintaining the integrity of the neuromuscular junction
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https://onlinelibrary.wiley.com/doi/abs/10.1002%2Fmus.24095
https://www.ncbi.nlm.nih.gov/pubmed/24122772
https://www.proquest.com/docview/1498115478/abstract/
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https://pubmed.ncbi.nlm.nih.gov/PMC4086464
Volume 49
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