Association of preoperative levels of selected blood inflammatory markers with prognosis in gliomas

• Published in: OncoTargets and therapy Vol. 9; pp. 6111 - 6117
• Main Authors: Auezova, Raushan, Ryskeldiev, Nurzhan, Doskaliyev, Aidos, Kuanyshev, Yerbol, Zhetpisbaev, Berik, Aldiyarova, Nurgul, Ivanova, Natalia, Akshulakov, Serik, Auezova, Lizette
• Format: Journal Article
• Language: English
• Published: New Zealand Dove Medical Press Limited 01.01.2016; Taylor & Francis Ltd; Dove Medical Press
• Subjects: Age; Automation; Blood cell count; Blood tests; Brain cancer; Brain research; Cancer therapies; Care and treatment; Chronic illnesses; Development and progression; Diagnosis; Gastric cancer; Glioma; Gliomas; Health aspects; Hematology; Hemostasis; Inflammation; Lymphocytes; Medical prognosis; Mortality; Nervous system; Neurosurgery; Neutrophils; neutrophil–lymphocyte ratio; Older people; Original Research; Patients; Physiological aspects; platelet; Radiation therapy; red cell distribution width; Studies; Surgery; survival; Tumors; tumour grade; Kazakhstan; United States > US; Russia; glioma; platelet; neutrophil–lymphocyte ratio; red cell distribution width; survival; tumor grade
• ISSN: 1178-6930; 1178-6930
• DOI: 10.2147/OTT.S113606

Red cell distribution width (RDW), neutrophil-lymphocyte ratio (NLR), and platelet count (PLT) routinely tested as part of the complete blood count are indicative of systemic inflammation. The prognostic significance of NLR and PLT in cancer was demonstrated in many studies while the role of RDW has been hardly investigated. The present study aimed to assess the association of RDW, NLR, and PLT with survival and tumor grade in glioma patients. Clinical data from 178 patients with primary gliomas treated in a single institution were retrospectively analyzed. Receiver operating characteristic curves for cutoff value determination, Kaplan-Meier survival analysis, various bivariate tests, and univariate and multivariate Cox regression analyses were performed. Patients with high RDW (≥13.95) and NLR (≥4) levels had worse overall survival (OS) (Wilcoxon test, <0.026 and <0.003, respectively) while the effect of thrombocytosis (≥400×10 /L) on prognosis was not significant. Besides, a strong association between RDW and NLR was found (Spearman's rho =0.230, <0.02; =8.887, <0.03; Mann-Whitney -test, <0.017). Moreover, RDW and NLR were significantly associated with tumor grade. In univariate Cox analysis, elevated NLR (hazard ratio, HR 1.385; confidence interval, CI 1.020-1.881, <0.037), older age (HR 0.452, CI 0.329-0.621, <0), and higher tumor grade (HR 1.624, CI 1.187-2.223, <0.002) were associated with poor outcomes. In the multivariate analysis, tumor grade, age, and Karnofsky performance score were identified as being independently prognostic for OS. Preoperative NLR and RDW values can help to evaluate disease progression and outcomes in patients with gliomas, thereby contributing to patient follow-up optimization.