Alteration in Pain Modulation in Women With Persistent Pain After Lumpectomy: Influence of Catastrophizing

• Published in: Journal of pain and symptom management Vol. 46; no. 1; pp. 30 - 42
• Main Authors: Edwards, Robert R., PhD, Mensing, George, BA, Cahalan, Christine, BA, Greenbaum, Seth, BA, Narang, Sanjeet, MD, Belfer, Inna, MD, PhD, Schreiber, Kristin L., MD, PhD, Campbell, Claudia, PhD, Wasan, Ajay D., MD, Jamison, Robert N., PhD
• Format: Journal Article
• Language: English
• Published: New York, NY Elsevier Inc 01.07.2013; Elsevier
• Subjects: Aged; Anesthesia & Perioperative Care; Biological and medical sciences; Breast cancer; Breast Neoplasms - physiopathology; Breast Neoplasms - psychology; Breast Neoplasms - surgery; Catastrophic reactions; Catastrophization - physiopathology; Catastrophization - psychology; catastrophizing; Chronic pain; conditioned pain modulation; Cross-Sectional Studies; Female; Humans; Hyperalgesia; lumpectomy; Mastectomy, Segmental - adverse effects; Medical sciences; Middle Aged; Pain Measurement; Pain Medicine; Pain Perception - physiology; Pain Threshold - physiology; Pain, Postoperative - physiopathology; Pain, Postoperative - psychology; Pharmacology. Drug treatments; Postoperative pain; quantitative sensory testing; Surgery; temporal summation; Women; temporal summation; catastrophizing; lumpectomy; quantitative sensory testing; conditioned pain modulation; Hyperalgesia; Human; Nervous system diseases; Medical screening; Pain; Treatment; Surgery; Modulation; Adult; Female; Woman; Tumorectomy; Quantitative analysis
• ISSN: 0885-3924; 1873-6513
• DOI: 10.1016/j.jpainsymman.2012.06.016

Abstract Context Persistent pain is common after surgical treatment of breast cancer, but fairly little is known about the changes in sensory processing that accompany such pain syndromes. Objectives This study used quantitative sensory testing to compare psychophysical responses to standardized noxious stimulation in two groups of women who had previously undergone breast cancer surgery: women with ( n = 37) and without ( n = 34) persistent postoperative pain. Methods Participants underwent a single testing session in which responses to a variety of noxious stimuli were assessed. Results Findings suggested that women with chronic pain after breast cancer surgery display enhanced temporal summation of mechanical pain, deficits in endogenous pain inhibition, and more intense painful aftersensations compared with those without long-term pain. Some of these group differences were mediated by higher levels of pain catastrophizing in the group of women with persistent pain. Conclusion These findings suggest that persistent postoperative pain is associated with alterations in central nervous system pain-modulatory processes. Future treatment studies might benefit from targeting these pain-modulatory systems, and additional studies using functional neuroimaging methods might provide further valuable information about the pathophysiology of long-term postsurgical pain in women treated for breast cancer.