Nutritional status and lipid profile of HIV-positive children and adolescents using antiretroviral therapy

• Published in: Clinics (São Paulo, Brazil) Vol. 66; no. 6; pp. 997 - 1002
• Main Authors: Contri, Patricia Viganó, Berchielli, Érica Miranda, Tremeschin, Marina Hjertquist, de Moura Negrini, Bento Vidal, Salomão, Roberta Garcia, Monteiro, Jacqueline Pontes
• Format: Journal Article
• Language: English
• Published: Brazil Elsevier España, S.L.U 01.01.2011; Hospital das Clínicas da Faculdade de Medicina da Universidade de São Paulo; Faculdade de Medicina / USP; Elsevier España
• Subjects: Adolescent; Anthropometry; Antiretroviral Therapy, Highly Active - adverse effects; Body Composition - drug effects; Child; Child, Preschool; Children and adolescents; Clinical Science; Dyslipidemia; Energy Intake - drug effects; Female; Follow-Up Studies; HIV; HIV Infections - blood; HIV Infections - drug therapy; HIV Protease Inhibitors - adverse effects; Humans; Lipids - blood; Male; MEDICINE, GENERAL & INTERNAL; Nutritional status; Nutritional Status - drug effects; Protease inhibitor; Risk Factors; Statistics, Nonparametric; Time Factors; Children and adolescents; HIV; Protease inhibitor; Nutritional status; Dyslipidemia
• ISSN: 1807-5932; 1980-5322; 1980-5322
• DOI: 10.1590/S1807-59322011000600013

To describe nutritional status, body composition and lipid profile in children and adolescents receiving protease inhibitors. Fifty-nine patients, 23 treated with protease inhibitors (group 1) and 36 not using protease inhibitors (group 2). Their dietary intake, anthropometry, bioimpedance analysis and lipid profile variables were measured. There was no difference in nutritional status or body composition between groups at the beginning of the study. After 6 months of follow-up, there was an increase in weight and height in both groups, as well as in waist circumference and subscapular skinfold thickness. In group 2, body mass index and triceps skinfold thickness adequacy were significantly higher after 6 months of follow-up. The groups had similar energy and macronutrient intake at any time point. After 6 months, group 1 had a higher cholesterol intake and group 2 had a higher fiber intake. Triglyceride serum levels were significantly different between the groups, with higher values in G1, at any time point [G1: 153 mg/dl (30–344); 138 (58–378) versus G2: 76 mg/dl (29–378); 76 (29–378)]. After 6 months of follow-up, G1 had higher LDL-cholesterol than G2 [104 mg/dl (40–142) versus 82 (42–145)]. The use of protease inhibitors, per se, does not seem to significantly interfere with anthropometric measures, body composition and food intake of HIV-infected children and adolescents. However, this antiretroviral therapy was associated with a significant increase in triglyceride and LDL-cholesterol in our subjects.