Brain-derived neurotrophic factor and mental disorders

Brain-derived neurotrophic factor (BDNF) is a neurotrophin that modulates neuroplasticity in the brain, and is one of the most widely investigated molecule in psychiatric disorders. The researches of BDNF emcompassed the advance of investigative techniques of past decades. BDNF researches ranged fro...

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Bibliographic Details
Published inBiomedical Journal Vol. 43; no. 2; pp. 134 - 142
Main Authors Lin, Chin-Chuen, Huang, Tiao-Lai
Format Journal Article
LanguageEnglish
Published United States Elsevier B.V 01.04.2020
Chang Gung University
Elsevier
Subjects
Bipolar disorder
Brain-derived neurotrophic factor
Epigenetics
Major depressive disorder
Proteomics
Review
Schizophrenia
Epigenetics
Schizophrenia
Bipolar disorder
Brain-derived neurotrophic factor
Major depressive disorder
Proteomics
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Summary:Brain-derived neurotrophic factor (BDNF) is a neurotrophin that modulates neuroplasticity in the brain, and is one of the most widely investigated molecule in psychiatric disorders. The researches of BDNF emcompassed the advance of investigative techniques of past decades. BDNF researches ranged from protein quantilization, to RNA expression measurements, to DNA sequencing, and lately but not lastly, epigenetic studies. In this review, we will briefly address findings on BDNF protein levels, mRNA expression, Val66Met polymorphism, and epigenetic modifications, in schizophrenia, major depressive disorder (MDD), and bipolar disorder.
Bibliography:ObjectType-Article-2
SourceType-Scholarly Journals-1
ObjectType-Feature-3
content type line 23
ObjectType-Review-1
ISSN:2319-4170
2320-2890
DOI:10.1016/j.bj.2020.01.001