Circular HDAC9/microRNA-138/Sirtuin-1 Pathway Mediates Synaptic and Amyloid Precursor Protein Processing Deficits in Alzheimer’s Disease

• Published in: Neuroscience bulletin Vol. 35; no. 5; pp. 877 - 888
• Main Authors: Lu, Yanjun, Tan, Lu, Wang, Xiong
• Format: Journal Article
• Language: English
• Published: Singapore Springer Singapore 01.10.2019; Springer
• Subjects: Advertising executives; Aged; Aged, 80 and over; Alzheimer Disease - genetics; Alzheimer Disease - metabolism; Alzheimer Disease - pathology; Alzheimer's disease; Amyloid beta-protein; Amyloid beta-Protein Precursor - genetics; Amyloid beta-Protein Precursor - metabolism; Anatomy; Anesthesiology; Animals; Biomedical and Life Sciences; Biomedicine; Female; Hippocampus - metabolism; Hippocampus - pathology; Histone Deacetylases - genetics; Histone Deacetylases - metabolism; Human Physiology; Humans; Male; Mice; Mice, Transgenic; MicroRNA; MicroRNAs - genetics; MicroRNAs - metabolism; Middle Aged; Neurology; Neurosciences; Original; Original Article; Pain Medicine; Repressor Proteins - genetics; Repressor Proteins - metabolism; RNA, Circular - genetics; RNA, Circular - metabolism; Sirtuin 1 - genetics; Sirtuin 1 - metabolism; Synapses - genetics; Synapses - metabolism; Synapses - pathology; Sirtuin-1; microRNA; Circular RNA; Synapse; Alzheimer’s disease; Memory

Synaptic dysfunction and abnormal processing of amyloid precursor protein (APP) are early pathological features in Alzheimer’s disease (AD). Recently, non-coding RNAs such as microRNAs (miRNAs) and circular RNAs (circRNAs) have been reported to contribute to the pathogenesis of AD. We found an age-d...