The Essential Role of IL-17 as the Pathogenetic Link between Psoriasis and Metabolic-Associated Fatty Liver Disease

• Published in: Life (Basel, Switzerland) Vol. 13; no. 2; p. 419
• Main Authors: Olveira, Antonio, Augustin, Salvador, Benlloch, Salvador, Ampuero, Javier, Suárez-Pérez, Jorge Alonso, Armesto, Susana, Vilarrasa, Eva, Belinchón-Romero, Isabel, Herranz, Pedro, Crespo, Javier, Guimerá, Francisco, Gómez-Labrador, Lara, Martín, Víctor, Carrascosa, José Manuel
• Format: Journal Article
• Language: English
• Published: Switzerland MDPI AG 01.02.2023; MDPI
• Subjects: CD4 antigen; CD8 antigen; Chemokines; Cholangitis; Cirrhosis; Clinical trials; Complications and side effects; Development and progression; Diabetes; Fatty liver; Fibrosis; Granulocytes; Helper cells; Hepatitis; Hepatocellular carcinoma; Hepatocytes; IL-17; IL-17A; Inflammation; Inflammatory diseases; Insulin; Insulin resistance; Interleukin 17; Leukocytes (neutrophilic); Ligands; Liver; Liver cancer; Liver diseases; Lymphocytes; Lymphocytes T; Macrophages; MAFLD; Metabolic diseases; metabolic-associated fatty liver disease; Metabolism; Natural killer cells; Obesity; Pathogenesis; Patients; Psoriasis; Review; Risk factors; Skin diseases; Transplants & implants; Spain; MAFLD; IL-17A; metabolic-associated fatty liver disease; psoriasis; IL-17
• ISSN: 2075-1729; 2075-1729
• DOI: 10.3390/life13020419

Interleukin 17 (IL-17) is an effector cytokine that plays a key role in the pathogenesis of both psoriasis and metabolic-associated fatty liver disease (MAFLD), a condition that is more prevalent and severe in patients with psoriasis. In liver inflammation, IL-17 is mainly produced by CD4+ T (TH17) and CD8+ T cells (Tc17), although numerous other cells (macrophages, natural killer cells, neutrophils and Tγδ cells) also contribute to the production of IL-17. In hepatocytes, IL-17 mediates systemic inflammation and the recruitment of inflammatory cells to the liver, and it is also implicated in the development of fibrosis and insulin resistance. IL-17 levels have been correlated with progression from MAFLD to steatohepatitis, cirrhosis, and even hepatocellular carcinoma. Clinical trials have shown that inhibiting IL-17A in patients with psoriasis could potentially contribute to the improvement of metabolic and liver parameters. A better understanding of the key factors involved in the pathogenesis of these chronic inflammatory processes could potentially lead to more efficient treatment for both psoriasis and MAFLD, and help to develop holistic strategies to improve the management of these patients.