Mucins and associated glycan signatures in colon adenoma–carcinoma sequence: Prospective pathological implication(s) for early diagnosis of colon cancer

• Published in: Cancer letters Vol. 374; no. 2; pp. 304 - 314
• Main Authors: Krishn, Shiv Ram, Kaur, Sukhwinder, Smith, Lynette M, Johansson, Sonny L, Jain, Maneesh, Patel, Asish, Gautam, Shailendra K, Hollingsworth, Michael A, Mandel, Ulla, Clausen, Henrik, Lo, Wing-Cheong, Fan, Wai-Tong Louis, Manne, Upender, Batra, Surinder K
• Format: Journal Article
• Language: English
• Published: Ireland Elsevier Ireland Ltd 01.05.2016; Elsevier Limited
• Subjects: Adenoma; Adenoma - metabolism; Adenoma - pathology; Arrays; Biomarkers, Tumor - metabolism; Cancer; Colon; Colonic mucin; Colonic Neoplasms - metabolism; Colonic Neoplasms - pathology; Colorectal cancer; Confidence intervals; Early Detection of Cancer; Glycan; Hematology, Oncology and Palliative Medicine; Humans; Hyperplastic polyp; Immunohistochemistry; Immunophenotyping; Laboratories; Mortality; Mucins - metabolism; Multivariate Analysis; Polysaccharides - metabolism; Precancerous Conditions - metabolism; Precancerous Conditions - pathology; Statistical analysis; Studies; Tumors; sessile serrated adenoma/polyp; microsatellite instability; PLA; IHC; Colorectal cancer; 3,3′-diaminobenzidine; IBD; Adenoma; odds ratio; proximity ligation assay; Kirsten rat sarcoma viral oncogene; UC; CA 19-9; carbohydrate antigen 19-9; deleted in colorectal cancer; Hyperplastic polyp; MUC; SSA/P; ulcerative colitis; Colonic mucin; immunohistochemistry; CD; GI; MSI; mucin gene; OR; DAB; DCC; CI; hydrogen peroxide; tumor associated glycoprotein 72; Crohn's disease; IS; TAG72; Glycan; composite scores; inflammatory bowel disease; CS; gastrointestinal; H 2O 2; APC; adenomatous polyposis coli; CRC; intensity scores; confidence interval; KRAS; H2O2
• ISSN: 0304-3835; 1872-7980
• DOI: 10.1016/j.canlet.2016.02.016

Highlights • Comprehensive study of mucins and associated glycans during colon carcinogenesis. • Significant alteration of mucins MUC4, MUC17, MUC2, MUC5AC and glycans Tn/STn-MUC1. • MUC2/MUC5AC/MUC17 panel discriminates adenoma/adenocarcinoma from benign polyps.